A new insulin-mimetic bis(allixinato)zinc(II) complex: structure-activity relationship of zinc(II) complexes

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Yusuke AdachiHiromu Sakurai

Abstract

During the investigation of the development of insulin-mimetic zinc(II) complexes with a blood glucose-lowering effect in experimental diabetic animals, we found a potent bis(maltolato)zinc(II) complex, Zn(ma)(2), exhibiting significant insulin-mimetic effects in a type 2 diabetic animal model. By using this Zn(ma)(2) as the leading compound, we examined the in vitro and in vivo structure-activity relationships of Zn(ma)(2) and its related complexes. The in vitro insulin-mimetic activity of these complexes was determined by the inhibition of free fatty acid release and the enhancement of glucose uptake in isolated rat adipocytes treated with epinephrine. A new Zn(II) complex with allixin isolated from garlic, Zn(alx)(2), exhibited the highest insulin-mimetic activity among the complexes analyzed. The insulin-mimetic activity of the Zn(II) complexes examined strongly correlated (correlation coefficient=0.96) with the partition coefficient (log P) of the ligand, indicating that the activity of Zn(ma)(2)-related complexes depends on the lipophilicity of the ligand. The blood glucose-lowering effects of Zn(alx)(2) and Zn(ma)(2) were then compared, and both complexes were found to normalize hyperglycemia in KK- A(y) mice after a 14-...Continue Reading

References

Mar 1, 1975·Metabolism: Clinical and Experimental·T W BurnsG A Robison
Jan 1, 1978·Contributions to Nephrology·A HeidlandD Deppermann
Oct 1, 1978·Endocrinology·E R ArquillaS Miyamoto
Jan 1, 1992·Biological Trace Element Research·P FaureA Favier
Aug 1, 1992·Endocrine Reviews·H Yki-Järvinen
Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Mar 1, 1983·The American Journal of Clinical Nutrition·A S LevineJ E Morley
Aug 1, 1983·The American Journal of Medicine·W B KinlawC J McClain
Aug 1, 1980·Diabetes·L Coulston, P Dandona
Jul 28, 1995·Science·M A PelleymounterF Collins
Mar 7, 1997·The Journal of Biological Chemistry·L A Tartaglia
Feb 12, 1998·Biochemical and Biophysical Research Communications·M D PercivalJ P Falgueyret
May 8, 1998·Biochemical and Biophysical Research Communications·R B Harris
Aug 4, 1999·The Netherlands Journal of Medicine·L J WagenaarJ B Hoekstra
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·T J Kieffer, J F Habener
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Mar 10, 2001·Cell·B M Spiegelman, J S Flier
Mar 13, 2001·Biochemical and Biophysical Research Communications·Y YoshikawaY Kojima
Dec 26, 2001·Chemical Reviews·K H ThompsonC Orvig
Feb 28, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yutaka YoshikawaYoshitane Kojima
Mar 26, 2002·Chemical & Pharmaceutical Bulletin·Yukihiro KoderaKazuhisa Ono
Mar 26, 2002·Chemical & Pharmaceutical Bulletin·Yukihiro KoderaKazuhisa Ono
Jun 6, 2002·Diabetes, Obesity & Metabolism·N Al-DaghriS Kumar
Jun 27, 2002·Biochemical and Biophysical Research Communications·Ronit IlouzHagit Eldar-Finkelman
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rolando B CeddiaGary Sweeney
Aug 31, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hiromu Sakurai
Feb 11, 2003·Chemical & Pharmaceutical Bulletin·Yutaka YoshikawaYoshitane Kojima
Jul 2, 2003·Expert Opinion on Investigational Drugs·Hiromu SakuraiYusuke Adachi
Nov 1, 1959·Archives of Biochemistry and Biophysics·K SCHWARZ, W MERTZ
Apr 14, 1962·Nature·A H RUBENSTEING A ELLIOTT
Sep 29, 2004·Diabetes Care·Wolfgang Rathmann, Guido Giani

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Citations

Feb 7, 2013·Frontiers of Medicine·Xiao MiaoLu Cai
Feb 19, 2010·Biological Trace Element Research·Sivasankari S ManiKandaswamy Muthusamy
May 29, 2013·Biological Trace Element Research·Saori KadowakiShuichi Enomoto
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Li Li DiTao Lu
May 16, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hiroyuki YasuiHiromu Sakurai
Feb 22, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Akihiro NakayamaHiromu Sakurai
Jun 1, 2007·Expert Opinion on Drug Discovery·Hiromu Sakurai
Jan 15, 2011·Journal of Pharmaceutical and Biomedical Analysis·Eva A EnyedyTamás Kiss
May 16, 2009·The Journal of Nutritional Biochemistry·Judith JansenLothar Rink
Dec 2, 2006·Life Sciences·Yutaka YoshikawaHiromu Sakurai
Oct 21, 2006·Biochemical and Biophysical Research Communications·Yusuke AdachiHiromu Sakurai
Sep 19, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Priyanga RanasingheGodwin R Constantine
Feb 14, 2012·European Journal of Pharmacology·Kalavakunda VijayaraghavanSorimuthu Pillai Subramanian
Jun 1, 2005·Journal of Inorganic Biochemistry·Yutaka YoshikawaYoshitane Kojima
Feb 20, 2008·Journal of Inorganic Biochemistry·Eva Anna EnyedyTamás Kiss
Mar 4, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiromu Sakurai
Nov 13, 2010·Metallomics : Integrated Biometal Science·Hiromu SakuraiMasakazu Hattori
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hiromu Sakurai, Yusuke Adachi
Feb 28, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Aaron WeyDavid N Paglia
Mar 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chika Ifeanyi ChukwumaLimpho M Ramorobi
Jul 20, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Haina Zhang, Lu Cai
Jul 11, 2006·Journal of Inorganic Biochemistry·T JakuschL Horváth
Jul 14, 2021·Annual Review of Nutrition·Inga WesselsLothar Rink

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