A new intralesional therapy of cutaneous leishmaniasis with hypertonic sodium chloride solution

The Journal of Dermatology
K E Sharquie

Abstract

One hundred and fifty-eight lesions of acute cutaneous leishmaniasis in 70 patients were treated with hypertonic sodium chloride solution "HSCS" (88 lesions) or sodium stibogluconate (50 lesions); 20 lesions were left untreated as controls. The injections were given at 7-10 day intervals, and patients were followed-up for 42 days. "HSCS" was shown to be a very effective local therapy (96.05% cure rate) and was as effective as local sodium stibogluconate (96.42% cure rate). With both types of therapy, most lesions needed only one injection. Mild improvement was noticed 7-10 days after the first injection, and the cure was complete within 2-6 weeks (mean 4 weeks) of follow-up. None of the control lesions showed a cure within the six weeks follow-up. The mechanisms of action of both "HSCS" and sodium stibogluconate probably involve interference with the osmotic pressure of the cell cytoplasm of the parasites and lesional tissues. Scarring was either absent or minimal following healing of the treated lesions with both types of treatment. Post-inflammatory hyperpigmentation was observed in all patients. We strongly recommend intralesional "HSCS" as a cheap, safe, and effective local method for treating cutaneous leishmaniasis.

References

Jul 1, 1975·The British Journal of Dermatology·W A Griffiths, W Dutz
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Citations

Apr 24, 2007·Travel Medicine and Infectious Disease·Philippe Minodier, Philippe Parola
Jun 4, 1998·The Journal of Dermatology·K E SharquieD el-Yassin
May 3, 2014·PLoS Neglected Tropical Diseases·Caspar J HodiamontTom van Gool
Mar 22, 2001·Clinical and Experimental Dermatology·K E SharquieD J Al-Timimi
Jan 28, 1999·Memórias do Instituto Oswaldo Cruz·R A NajimI B Farjou
Jul 26, 2017·International Journal of Dermatology·Alberto E Paniz-MondolfiAlfonso J Rodriguez-Morales
Nov 18, 2017·The Cochrane Database of Systematic Reviews·Julio Heras-MosteiroRogelio López-Vélez
Dec 9, 2014·Jundishapur Journal of Microbiology·Ali Fattahi BafghiMahdi Aghabagheri
Feb 1, 2003·Clinical and Experimental Dermatology·G Faghihi, R Tavakoli-kia
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Urbà GonzálezJorge Alvar
Sep 8, 2010·The Journal of Dermatological Treatment·Ranthilaka R RanawakaNandimithra Opathella
Dec 2, 2017·The Cochrane Database of Systematic Reviews·Julio Heras-MosteiroRogelio López-Vélez
Apr 18, 2018·International Journal of Dermatology·Soner UzunMehmet Harman
Jan 30, 2007·Annals of Saudi Medicine·Khalifa A Sharquie, Adil A Al-Nuaimy
Oct 25, 2020·Journal of Cosmetic Dermatology·Heba Saed El-Amawy, Sameh Magdy Sarsik

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