A new ischemic model using a radiofrequency wire electrode in a rabbit hindlimb

Cardiovascular and Interventional Radiology
Hye Won BaikKun Sang Kim


The purpose of this study was to establish an ischemic rabbit hindlimb model using a radiofrequency (RF) wire electrode. We inserted a polytetrafluoroethylene-coated wire with a 2-cm exposed tip into the left superficial femoral artery of seven New Zealand white rabbits and performed RF ablation (RFA) while pulling the wire back. We assessed the clinical findings, angiography, computed tomography perfusion, and permeability surface until 6 weeks after RFA. The angiography demonstrated complete obstruction from the proximal external iliac artery to the distal superficial femoral artery and showed a gradual increment in the angiogenic score, which represents the degree of angiogenesis (r = 0.86, p < 0.0001). The left-to-right ratios of the computed tomography perfusion and permeability surface were significantly reduced after 4 days (p < 0.05), and then they gradually increased with time. We conclude that endovascular RFA using an RF wire electrode is a reproducible and measurable way to create an ischemic rabbit hindlimb model.


Jan 1, 1979·Journal of the Neurological Sciences·K A Kelts, K K Kaiser
Nov 1, 1990·The Journal of Surgical Research·D L HendricksD L Steed
Mar 1, 1988·The Journal of Surgical Research·P S Barie, R J Mullins
Jul 1, 1988·Stroke; a Journal of Cerebral Circulation·E MoriA Yamadori
Jan 1, 1980·Cardiovascular and Interventional Radiology·W M Thompson, I S Johnsrude
Jan 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·L Q PuJ F Symes
Oct 20, 2001·Journal of Korean Medical Science·J H HongJ H Park
Jan 5, 2002·Physics in Medicine and Biology·T G PurdieT Y Lee
May 7, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Weiss, Margaret A Weiss
Jun 7, 2002·Journal of Vascular and Interventional Radiology : JVIR·John J BerganSteven R Sparks
Jun 7, 2002·Journal of Vascular and Interventional Radiology : JVIR·Tero T RautioKari A Haukipuro
Apr 9, 2004·Techniques in Vascular and Interventional Radiology·Robert P LiddellLawrence V Hofmann
Jul 9, 2005·Journal of Vascular and Interventional Radiology : JVIR·Robert P LiddellLawrence V Hofmann

❮ Previous
Next ❯


May 3, 2011·Journal of Vascular and Interventional Radiology : JVIR·Byung Kook KwakDong Un Kim
Dec 25, 2009·Journal of Vascular and Interventional Radiology : JVIR·Marcelo GuimaraesRenan Uflacker
Jun 11, 2008·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Byung Kook Kwak, Hyung Jin Shim

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
Byung Kook Kwak, Hyung Jin Shim
© 2021 Meta ULC. All rights reserved