A new ischemic model using a radiofrequency wire electrode in a rabbit hindlimb

Cardiovascular and Interventional Radiology
Hye Won BaikKun Sang Kim

Abstract

The purpose of this study was to establish an ischemic rabbit hindlimb model using a radiofrequency (RF) wire electrode. We inserted a polytetrafluoroethylene-coated wire with a 2-cm exposed tip into the left superficial femoral artery of seven New Zealand white rabbits and performed RF ablation (RFA) while pulling the wire back. We assessed the clinical findings, angiography, computed tomography perfusion, and permeability surface until 6 weeks after RFA. The angiography demonstrated complete obstruction from the proximal external iliac artery to the distal superficial femoral artery and showed a gradual increment in the angiogenic score, which represents the degree of angiogenesis (r = 0.86, p < 0.0001). The left-to-right ratios of the computed tomography perfusion and permeability surface were significantly reduced after 4 days (p < 0.05), and then they gradually increased with time. We conclude that endovascular RFA using an RF wire electrode is a reproducible and measurable way to create an ischemic rabbit hindlimb model.

References

Jan 1, 1979·Journal of the Neurological Sciences·K A Kelts, K K Kaiser
Nov 1, 1990·The Journal of Surgical Research·D L HendricksD L Steed
Mar 1, 1988·The Journal of Surgical Research·P S Barie, R J Mullins
Jul 1, 1988·Stroke; a Journal of Cerebral Circulation·E MoriA Yamadori
Jan 1, 1980·Cardiovascular and Interventional Radiology·W M Thompson, I S Johnsrude
Jan 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·L Q PuJ F Symes
Oct 20, 2001·Journal of Korean Medical Science·J H HongJ H Park
Jan 5, 2002·Physics in Medicine and Biology·T G PurdieT Y Lee
May 7, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Weiss, Margaret A Weiss
Jun 7, 2002·Journal of Vascular and Interventional Radiology : JVIR·John J BerganSteven R Sparks
Jun 7, 2002·Journal of Vascular and Interventional Radiology : JVIR·Tero T RautioKari A Haukipuro
Apr 9, 2004·Techniques in Vascular and Interventional Radiology·Robert P LiddellLawrence V Hofmann
Jul 9, 2005·Journal of Vascular and Interventional Radiology : JVIR·Robert P LiddellLawrence V Hofmann

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Citations

May 3, 2011·Journal of Vascular and Interventional Radiology : JVIR·Byung Kook KwakDong Un Kim
Dec 25, 2009·Journal of Vascular and Interventional Radiology : JVIR·Marcelo GuimaraesRenan Uflacker
Jun 11, 2008·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Byung Kook Kwak, Hyung Jin Shim

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