A new light on an old disease: adhesion signaling in pemphigus vulgaris

The Journal of Investigative Dermatology
Arnaud GalichetEliane J Müller

Abstract

Disruption of desmosomal cadherin adhesion leads to the activation of intracellular signaling pathways that are responsible for blister formation in pemphigus vulgaris (PV). Recent studies corroborate the implication of the p38 mitogen-activated protein kinase in PV blistering via its downstream effector mitogen-activated protein kinase activated protein kinase 2. These insights highlight the key role of cadherins in tissue homeostasis and are expected to change pemphigus management.

References

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Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Paula BerkowitzDavid S Rubenstein
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Feb 13, 2008·The Journal of Investigative Dermatology·Eliane J MüllerMaja M Suter
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Citations

Nov 26, 2015·Seminars in Immunopathology·Giovanni Di ZenzoLuca Borradori
Aug 16, 2014·Veterinary Dermatology·Eliane J MüllerMaja M Suter
Dec 3, 2014·Immunology Letters·Caleb CornabyBrian D Poole
Oct 30, 2016·Experimental Dermatology·A Razzaque AhmedSergei A Grando
Dec 6, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Emily F ColeRon J Feldman
Jan 10, 2018·Clinical Reviews in Allergy & Immunology·Robert PollmannMichael Hertl

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