PMID: 9429146Jan 16, 1998Paper

A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22

Journal of Medical Genetics
D A CampbellR F Mueller

Abstract

Non-syndromal, recessive deafness (NSRD) is the most common form of inherited deafness or hearing impairment in humans. NSRD is genetically heterogeneous and it has been estimated that as many as 35 different loci may be involved. We report the mapping of a novel locus for autosomal recessive, non-syndromal deafness (DFNB16) in three consanguineous families originating from Pakistan and the Middle East. Using multipoint analysis (HOMOZ/MAPMAKER) a maximum combined lod score of 6.5 was obtained for the interval D15S1039-D15S123. Recombination events and haplotype analysis define a 12-14 cM critical region between the markers D15S1039 and D15S155 on chromosome 15q15-q21.

References

Sep 15, 1996·Genomics·T HassonN A Jenkins

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Citations

Feb 16, 2005·Human Genetics·Jamil AhmadSheikh Riazuddin
May 20, 1999·Clinical Genetics·N G Robertson, C C Morton
Aug 4, 2001·Molecular and Cellular Biology·W YangS L Mansour
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Jul 25, 2020·International Journal of Pediatric Otorhinolaryngology·T G MarkovaG A Tavartkiladze

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