A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-κB

Archives of Pharmacal Research
Jeong Ah KimYoung Ho Kim

Abstract

A new lupane-triterpene, 3β-cis-feruloyloxy-16β-hydroxylup-20(29)-ene (1) were isolated from the ethyl acetate extract of Panax ginseng seeds along with the known compound, 3β-transferuloyloxy-16β-hydroxylup-20(29)-ene (2). Compound 2 was isolated from this plant for the first time. Their chemical structures were determined by mass spectroscopy and one-dimensional and two-dimensional magnetic resonance spectra. The bioactive effects of these compounds on TNF-α-induced NF-κB transcription were evaluated in transfected HepG2 cells. Effects on the expression of NF-κB target genes were also examined using a reverse transcription-polymerase chain reaction. Both compounds 1 and 2 were inhibited NF-κB activity in HepG2 cells by decreasing the cellular concentrations of inflammatory factors iNOS and COX2.

References

Dec 17, 2002·Phytochemistry·Bang Yeon HwangA Douglas Kinghorn
Jun 28, 2003·Journal of Natural Products·Fredyc DíazA Douglas Kinghorn
Sep 13, 2011·Archives of Pharmacal Research·Jeong Ah KimYoung Ho Kim

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Citations

Jul 6, 2014·Pharmacognosy Magazine·Yeonmi LeeSang Yoon Choi
May 29, 2014·Journal of Ethnopharmacology·Eunji KimJae Youl Cho
Oct 25, 2014·Natural Product Reports·Robert A Hill, Joseph D Connolly
May 20, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jun ZhangHaiping Hao
Feb 20, 2013·Journal of Agricultural and Food Chemistry·Christelle M AndreWilliam A Laing

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