A New Lycopodine-type Alkaloid from Lycopodium japonicum

Natural Product Research
Qian YangYegao Chen

Abstract

A new lycopodine-type alkaloid, 12β-hydroxy-acetylfawcettiine N-oxide (1), together with seven known analogues, acetyllycoposerramine M (2), lycopodine (3), lycoclavine (4), diphaladine A (5), lycoposerramine K (6), 11β-hydroxy-12-epilycodoline (7) and fawcettiine (8), were isolated from Lycopodium japonicum. Their structures were established by mass spectrometry and 1D and 2D NMR techniques. The isolated alkaloids were assayed for their inhibition activities against acetylcholinesterase, but no inhibitory activities for the compounds were detected.

References

Jul 17, 2003·Planta medica·Xiao-Tian TongDa-Yuan Zhu
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Oct 2, 2008·Chemical & Pharmaceutical Bulletin·Yusuke HirasawaHiroshi Morita
Aug 5, 2009·Chemical & Pharmaceutical Bulletin·Kan'ichiro IshiuchiJun'ichi Kobayashi
Sep 14, 2012·Chemical & Pharmaceutical Bulletin·Bo LiYun-Heng Shen
Nov 6, 2012·Organic Letters·Xiao-Jing WangYong Li
Aug 26, 2014·Journal of the American Chemical Society·Amy S LeeMatthew D Shair
Nov 26, 2014·Natural Product Research·Jichun WuYegao Chen
Jul 15, 2015·Natural Product Research·Zhichong WangYegao Chen

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