PMID: 8952960Jan 1, 1996Paper

A new major histocompatibility complex class I b gene expressed in the mouse blastocyst and placenta

Immunogenetics
S L SipesC P Landel

Abstract

Because of the role major histocompatibility complex (MHC) class I b molecules may play during mouse embryonic development, we thought it would be interesting to search for additional MHC class I b molecules that might be expressed in preimplantation embryos, and in particular in the trophoblastic lineage. We therefore screened a mouse preimplantation blastocyst cDNA library for MHC class I sequences. This search led to the identification and characterization of a new MHC class I b gene, blastocyst MHC. Sequences identical to the exons and 3' untranslated region of this gene have been found in many laboratory mouse strains, as well as in the related mouse species Mus spreciligus. The presence of this gene in mouse strains of different MHC class I haplotypes argues that blastocyst MHC is a unique, newly-described gene rather than a new allele of a previously described mouse MHC class I gene. Blastocyst MHC has the structure of an MHC class I b gene, with the six exons characteristic of T-region genes. It is linked to H2-D. The amino acid sequence encoded by this gene maintains all the features of a functional antigen-presentation domain. The blastocyst MHC gene, like the human class I b gene HLA-G, is expressed at the blastocyst...Continue Reading

Citations

Jun 2, 2006·Immunogenetics·Nicolas GouinRobert D Miller
May 18, 2005·Biochemical and Biophysical Research Communications·Toshitaka TanakaHideo Yagita
Jun 2, 2005·Nature Reviews. Immunology·John R Rodgers, Richard G Cook
Aug 30, 2000·Proceedings of the Society for Experimental Biology and Medicine·M J SoloskiS L Wooden
May 13, 1999·Immunological Reviews·C AmadouK F Lindahl
May 13, 1999·Immunological Reviews·P Le Bouteiller, A Blaschitz
Mar 31, 1999·American Journal of Reproductive Immunology : AJRI·T J Gill
Apr 2, 1999·American Journal of Reproductive Immunology : AJRI·D A Clark
Dec 2, 1999·American Journal of Reproductive Immunology : AJRI·G Chaouat
Jun 23, 1999·American Journal of Reproductive Immunology : AJRI·T V Hviid, N Morling
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·W M Yokoyama
Mar 9, 2002·American Journal of Reproductive Immunology : AJRI·Sayantani BasakChandana Das
Jan 30, 2020·The Journal of Biological Chemistry·Katharine Jennifer GoodallDaniel Mark Andrews
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsushi TajimaHideo Yagita
Jan 1, 1997·Hereditas·M YoshinoK Fischer Lindahl
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beckley K DavisJohn R Rodgers
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paula A Guidry, Iwona Stroynowski

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