A new measure of centrality for brain networks

PloS One
Karen E JoyceSatoru Hayasaka


Recent developments in network theory have allowed for the study of the structure and function of the human brain in terms of a network of interconnected components. Among the many nodes that form a network, some play a crucial role and are said to be central within the network structure. Central nodes may be identified via centrality metrics, with degree, betweenness, and eigenvector centrality being three of the most popular measures. Degree identifies the most connected nodes, whereas betweenness centrality identifies those located on the most traveled paths. Eigenvector centrality considers nodes connected to other high degree nodes as highly central. In the work presented here, we propose a new centrality metric called leverage centrality that considers the extent of connectivity of a node relative to the connectivity of its neighbors. The leverage centrality of a node in a network is determined by the extent to which its immediate neighbors rely on that node for information. Although similar in concept, there are essential differences between eigenvector and leverage centrality that are discussed in this manuscript. Degree, betweenness, eigenvector, and leverage centrality were compared using functional brain networks gen...Continue Reading


Jan 1, 1974·Scandinavian Journal of Psychology·J Nieminen
Dec 1, 1966·Psychometrika·G Sabidussi
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Oct 16, 1999·Science·A L Barabasi, R Albert
Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C C HilgetagM P Young
May 4, 2002·Science·Sergei Maslov, Kim Sneppen
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·M Girvan, M E J Newman
Nov 22, 2002·Physical Review Letters·M E J Newman
Mar 15, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M E J Newman
Jul 13, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M E J Newman
Feb 9, 2005·Physical Review Letters·Victor M EguíluzA Vania Apkarian
Feb 25, 2005·Nature·Roger Guimerà, Luís A Nunes Amaral
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ernesto Estrada, Juan A Rodríguez-Velázquez
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M E J Newman
Oct 3, 2007·Nonlinear Biomedical Physics·Cornelis J Stam, Jaap C Reijneveld
Oct 18, 2007·PloS One·Olaf SpornsRolf Kötter
Dec 12, 2007·Human Brain Mapping·Ann M PeifferPaul J Laurienti
Mar 21, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jianhua Ruan, Weixiong Zhang
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Vincent D BlondelRenaud Lambiotte
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Jul 2, 2009·Chaos·M ValenciaMario Chavez
Dec 2, 2009·Frontiers in Neuroinformatics·David MeunierEdward T Bullmore
Dec 29, 2009·NeuroImage·Andrew ZaleskyEdward T Bullmore
Nov 12, 1986·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner


Sep 3, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Fabrizio De Vico FallaniSophie Achard
Jun 20, 2014·Brain Connectivity·Walter S PritchardSatoru Hayasaka
Jun 8, 2011·PloS One·Sean L SimpsonPaul J Laurienti
Jan 30, 2013·PLoS Computational Biology·Karen E JoycePaul J Laurienti
Sep 27, 2013·PloS One·Guo-Rong WuDaniele Marinazzo
Oct 5, 2011·Cerebral Cortex·Xi-Nian ZuoMichael P Milham
Jan 1, 2011·Brain Connectivity·Qawi K TelesfordPaul J Laurienti
Jun 27, 2012·Neural Networks : the Official Journal of the International Neural Network Society·Karen E JoyceSatoru Hayasaka
Dec 8, 2015·Scientific Reports·Josepheen De Asis-CruzCatherine Limperopoulos
Aug 16, 2014·Seizure : the Journal of the British Epilepsy Association·Zulfi Haneef, Sharon Chiang
Nov 26, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiaolong QinQing Lu
Oct 16, 2015·Medical & Biological Engineering & Computing·E Ruiz VargasL M Wahl
Dec 17, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Eric van DiessenCornelis J Stam
Sep 13, 2011·Current Opinion in Neurobiology·Timothy E J Behrens, Olaf Sporns
Aug 27, 2013·Neuron·Jonathan D PowerSteven E Petersen
Dec 19, 2014·Frontiers in Human Neuroscience·Matthew L StanleyPaul J Laurienti
Mar 13, 2014·Diabetes·David EndesfelderAnette-G Ziegler
Sep 7, 2012·PloS One·Malaak N MoussaSatoru Hayasaka
Jun 9, 2016·Scientific Reports·Michael T Gastner, Géza Ódor
Apr 27, 2016·Scientific Reports·Soibam Shyamchand SinghR K Brojen Singh
Jan 3, 2018·Brain : a Journal of Neurology·Thomas E CopeJames B Rowe
Feb 9, 2017·Brain Connectivity·Nantia D Iakovidou
Aug 2, 2018·BMC Systems Biology·Minoo AshtianiMohieddin Jafari
Sep 3, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David PapoJavier M Buldú
Jul 25, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Sara ColloroneMAGNIMS Study Group
Mar 4, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Dominic LangloisJ P Thivierge
Jun 24, 2016·Brain Structure & Function·Andrea Avena-KoenigsbergerOlaf Sporns
May 23, 2020·PloS One·Andrea Fronzetti Colladon, Maurizio Naldi

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

© 2021 Meta ULC. All rights reserved