A New Medical Device Rigeneracons Allows to Obtain Viable Micro-Grafts From Mechanical Disaggregation of Human Tissues

Journal of Cellular Physiology
Letizia TrovatoAntonio Graziano

Abstract

Autologous graft is considered the gold standard of graft materials; however, this approach is still limited due to both small amount of tissue that can be collected and to reduced cell viability of cells that can be obtained. The aim of this preliminary study was to demonstrate the efficacy of an innovative medical device called Rigeneracons® (CE certified Class I) to provide autologous micro-grafts immediately available to be used in the clinical practice. Moreover, Rigeneracons® is an instrument able to create micro-grafts enriched of progenitors cells which maintain their regenerative and differentiation potential. We reported preliminary data about viability cell of samples derived from different kind of human tissues, such as periosteum, cardiac atrial appendage biopsy, and lateral rectus muscle of eyeball and disaggregated by Rigeneracons®. In all cases we observed that micro-grafts obtained by Rigeneracons® displayed high cell viability. Furthermore, by cell characterization of periosteum samples, we also evidenced an high positivity to mesenchymal cell markers, suggesting an optimal regenerative potential.

References

Oct 14, 2005·Journal of Cellular Physiology·Gregorio LainoGianpaolo Papaccio
Jun 15, 2007·Journal of Cellular Physiology·Antonio GrazianoGianpaolo Papaccio
Jan 24, 2008·Cell Proliferation·A GrazianoG Papaccio
Nov 1, 2013·Journal of Indian Society of Periodontology·Giorgio BrunelliFrancesco Carinci
Aug 16, 2014·World Journal of Stem Cells·Mohamadreza Baghaban Eslaminejad, Elham Malakooty Poor

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Citations

Jan 31, 2016·Journal of Cosmetic Dermatology·Fabiano SvolacchiaGiuseppe A Ferraro
Apr 30, 2016·International Wound Journal·Marco MarcarelliAntonio Graziano
Jul 15, 2016·Cancer Biology & Therapy·Francesco De FrancescoUmberto Cillo
Feb 25, 2017·Journal of Cellular Physiology·Sawako NodaIzumi Asahina
Aug 3, 2017·International Journal of Molecular Sciences·Shiro JimiHiroyuki Ohjimi
May 4, 2018·Sports Medicine and Arthroscopy Review·Isabel AndiaNicola Maffulli
Jan 10, 2019·Journal of Clinical Periodontology·Siddharth ShanbhagKamal Mustafa
Oct 24, 2019·Journal of Cellular Physiology·Rafael G RuizAntonio Graziano
Jun 10, 2016·Journal of Cellular Physiology·Manuela MontiRuggero Rodriguez Y Baena
May 13, 2017·International Journal of Molecular Sciences·Francesco De FrancescoGiuseppe A Ferraro
Nov 8, 2018·Journal of Orthopaedic Surgery and Research·Marco ViganòLaura de Girolamo
Nov 7, 2019·Stem Cells Translational Medicine·Federico Moreno SanchoFrancesco D'Aiuto
Sep 22, 2020·The Journal of Dermatology·Giovanni Menchini, Carlo Astarita
Oct 5, 2019·Stem Cells International·Marco Mario TresoldiGiovanni Nicoletti
Jun 17, 2020·The Journal of International Medical Research·Carlo AstaritaLetizia Trovato
May 21, 2019·SAGE Open Medical Case Reports·Miyuki Uehara, Fumiaki Shimizu
Jun 22, 2017·Pharmaceuticals·Francesca VitaliRiccardo Bellazzi
Mar 25, 2017·Stem Cells International·Gabriele CeccarelliRuggero Rodriguez Y Baena
Aug 25, 2018·Case Reports in Dentistry·Saturnino Marco LupiRuggero Rodriguez Y Baena
Oct 13, 2017·Frontiers in Cell and Developmental Biology·Ruggero Rodriguez Y BaenaSaturnino M Lupi
Jan 19, 2021·Case Reports in Plastic Surgery & Hand Surgery·G MiottiP C Parodi
Apr 27, 2021·Journal of Clinical Periodontology·Danae A ApatzidouAntonis Konstantinidis

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