PMID: 6429346Jan 1, 1984Paper

A new method for calculating evolutionary substitution rates

Journal of Molecular Evolution
C LanaveG Serio


In this paper we present a new method for analysing molecular evolution in homologous genes based on a general stationary Markov process. The elaborate statistical analysis necessary to apply the method effectively has been performed using Monte Carlo techniques. We have applied our method to the silent third position of the codon of the five mitochondrial genes coding for identified proteins of four mammalian species (rat, mouse, cow and man). We found that the method applies satisfactorily to the three former species, while the last appears to be outside the scope of the present approach. The method allows one to calculate the evolutionarily effective silent substitution rate (vs) for mitochondrial genes, which in the species mentioned above is 1.4 X 10(-8) nucleotide substitutions per site per year. We have also determined the divergence time ratios between the couples mouse-cow/rat-mouse and rat-cow/rat-mouse. In both cases this value is approximately 1.4.


Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W M BrownA C Wilson
Jan 1, 1977·Annual Review of Biochemistry·A C WilsonT J White
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M Kimura
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T MiyataT Nishida
Apr 9, 1981·Nature·S AndersonI G Young
Oct 1, 1981·Cell·M J BibbD A Clayton
Jun 1, 1980·Cell·F PerlerJ Dodgson

❮ Previous
Next ❯


Dec 19, 2001·American Journal of Physical Anthropology·M Tommaseo-PonzettaC Saccone
Sep 1, 1994·Journal of Molecular Evolution·A Zharkikh
Mar 1, 1995·Journal of Molecular Evolution·C SacconeG Pesole
Feb 1, 1993·Journal of Molecular Evolution·N Goldman
Jan 1, 1991·Journal of Molecular Evolution·M Long, J H Gillespie
Jan 1, 1991·Journal of Molecular Evolution·M Hasegawa, S Horai
Aug 1, 1990·Journal of Molecular Evolution·D Mouchiroud, C Gautier
Jan 1, 1987·Journal of Molecular Evolution·G Preparata, C Saccone
Jan 1, 1984·Journal of Molecular Evolution·C LanaveC Saccone
Aug 1, 1993·Journal of Molecular Evolution·C SacconeG Pesole
Nov 1, 1989·Journal of Molecular Evolution·C SacconeG Preparata
Jun 6, 2006·Journal of Molecular Evolution·Lars Arvestad
May 5, 2005·Journal of Molecular Evolution·Susanne SchmittMatthias Wolf
Mar 25, 2009·Journal of Molecular Evolution·Alexis Criscuolo, Christian J Michel
Jul 10, 2008·Oecologia·Marcus ClaussJürgen Hummel
Jun 21, 2008·Archives of Virology·A J GibbsM J Gibbs
Nov 26, 2008·Archives of Virology·A J GibbsM J Gibbs
Mar 24, 2012·Plant Molecular Biology·Thomas Braukmann, Saša Stefanović
Apr 1, 1996·Mathematical Biosciences·C Kelly, J Rice
Apr 10, 2012·Journal of Microbiological Methods·Jorunn Pauline CavanaghJohanna Ericson Sollid
Apr 7, 2007·Theory in Biosciences = Theorie in Den Biowissenschaften·Anup Som
Apr 6, 2004·Molecular Phylogenetics and Evolution·Ignacio Doadrio, Omar Domínguez
Apr 5, 1990·Journal of Theoretical Biology·M SchönigerB Borstnik
Aug 10, 2000·Trends in Ecology & Evolution·A Ø Mooers, E C Holmes
Jun 19, 2002·Molecular Phylogenetics and Evolution·William J Hahn
Jul 30, 2002·Molecular Phylogenetics and Evolution·Eric P PalkovacsAdalgisa Caccone

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.