PMID: 6429346Jan 1, 1984Paper

A new method for calculating evolutionary substitution rates

Journal of Molecular Evolution
C LanaveG Serio

Abstract

In this paper we present a new method for analysing molecular evolution in homologous genes based on a general stationary Markov process. The elaborate statistical analysis necessary to apply the method effectively has been performed using Monte Carlo techniques. We have applied our method to the silent third position of the codon of the five mitochondrial genes coding for identified proteins of four mammalian species (rat, mouse, cow and man). We found that the method applies satisfactorily to the three former species, while the last appears to be outside the scope of the present approach. The method allows one to calculate the evolutionarily effective silent substitution rate (vs) for mitochondrial genes, which in the species mentioned above is 1.4 X 10(-8) nucleotide substitutions per site per year. We have also determined the divergence time ratios between the couples mouse-cow/rat-mouse and rat-cow/rat-mouse. In both cases this value is approximately 1.4.

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Citations

Dec 19, 2001·American Journal of Physical Anthropology·M Tommaseo-PonzettaC Saccone
Sep 1, 1994·Journal of Molecular Evolution·A Zharkikh
Mar 1, 1995·Journal of Molecular Evolution·C SacconeG Pesole
Feb 1, 1993·Journal of Molecular Evolution·N Goldman
Jan 1, 1991·Journal of Molecular Evolution·M Long, J H Gillespie
Jan 1, 1991·Journal of Molecular Evolution·M Hasegawa, S Horai
Aug 1, 1990·Journal of Molecular Evolution·D Mouchiroud, C Gautier
Jan 1, 1987·Journal of Molecular Evolution·G Preparata, C Saccone
Jan 1, 1984·Journal of Molecular Evolution·C LanaveC Saccone
Aug 1, 1993·Journal of Molecular Evolution·C SacconeG Pesole
Nov 1, 1989·Journal of Molecular Evolution·C SacconeG Preparata
Jun 6, 2006·Journal of Molecular Evolution·Lars Arvestad
May 5, 2005·Journal of Molecular Evolution·Susanne SchmittMatthias Wolf
Mar 25, 2009·Journal of Molecular Evolution·Alexis Criscuolo, Christian J Michel
Jul 10, 2008·Oecologia·Marcus ClaussJürgen Hummel
Jun 21, 2008·Archives of Virology·A J GibbsM J Gibbs
Nov 26, 2008·Archives of Virology·A J GibbsM J Gibbs
Mar 24, 2012·Plant Molecular Biology·Thomas Braukmann, Saša Stefanović
Apr 1, 1996·Mathematical Biosciences·C Kelly, J Rice
Apr 10, 2012·Journal of Microbiological Methods·Jorunn Pauline CavanaghJohanna Ericson Sollid
Apr 7, 2007·Theory in Biosciences = Theorie in Den Biowissenschaften·Anup Som
Apr 6, 2004·Molecular Phylogenetics and Evolution·Ignacio Doadrio, Omar Domínguez
Apr 5, 1990·Journal of Theoretical Biology·M SchönigerB Borstnik
Aug 10, 2000·Trends in Ecology & Evolution·A Ø Mooers, E C Holmes
Jun 19, 2002·Molecular Phylogenetics and Evolution·William J Hahn
Jul 30, 2002·Molecular Phylogenetics and Evolution·Eric P PalkovacsAdalgisa Caccone

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