PMID: 11920763Mar 29, 2002Paper

A new method for characterizing the release of drugs from tablets in low liquid surroundings

Journal of Pharmaceutical Sciences
G FrenningM Strømme

Abstract

The purpose of this article is to introduce a method capable of determining early drug dissolution in small amounts of liquid. The method is based on the measurement of the alternating ionic current through a cell containing the dissolution medium and the substance to be dissolved. Both the initial and more prolonged absorption of liquid into tablets can also be determined by using the same technique. The method has been tested on two tablet formulations containing agglomerated micronized cellulose and NaCl as a model drug. Release of NaCl was delayed from both formulations; the extent of the delay was strongly formulation-dependent only when the surrounding liquid was in short supply. This finding shows that new drug dissolution phenomena may be encountered in small liquid volumes; these phenomena would not have been seen with the large volume methods normally used in in vitro dissolution tests. Hence, for formulations intended for sublingual, buccal, or rectal administration, i.e., in areas where liquid is scarce, in vitro dissolution tests should be performed in small volumes of dissolution medium.

References

Apr 1, 1968·The Journal of Pharmacy and Pharmacology·J Polderman, D R Braakman
May 10, 2000·International Journal of Pharmaceutics·M Strømme MattssonR Ek
Aug 1, 2000·International Journal of Pharmaceutics·P HedenusR Ek

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Citations

May 19, 2009·Journal of Materials Science. Materials in Medicine·Jonas AbergHåkan Engqvist
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·W WeyenbergA Ludwig
Dec 14, 2002·International Journal of Pharmaceutics·G Frenning, M Strømme
Nov 10, 2009·The Review of Scientific Instruments·Ville RimpiläinenJarkko Ketolainen
Oct 23, 2003·Drug Development and Industrial Pharmacy·Jinsong Hao, Paul W S Heng
Jun 4, 2004·Journal of Pharmaceutical Sciences·Ulrika BrohedeMaria Strømme
Aug 28, 2007·Journal of Pharmaceutical Sciences·U BrohedeG Frenning
Apr 10, 2015·Journal of Pharmaceutical Sciences·Tobias WerkHanns-Christian Mahler
Apr 24, 2009·Journal of Pharmaceutical Sciences·Jason T McConvilleHoward N E Stevens
May 23, 2003·Journal of Pharmaceutical Sciences·Ken Welch, Maria Strømme
Apr 11, 2012·International Journal of Pharmaceutics·Poonam R DelvadiaH Thomas Karnes
Jul 27, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ville RimpiläinenLasse M Heikkinen
Feb 2, 2010·Journal of Pharmaceutical and Biomedical Analysis·Riikka LaitinenJarkko Ketolainen
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Maria StrømmeAlfonso E Garcia-Bennett
Aug 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Göran FrenningMaria Strømme
Jun 13, 2012·The Journal of Pharmacy and Pharmacology·Johannes KraemerAkif Tuereli
Jun 8, 2012·Biopharmaceutics & Drug Disposition·Jayachandar GajendranPeter Langguth
Mar 14, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Maria StrømmeAlfonso E Garcia-Bennett
Aug 19, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Alfonso E Garcia-BennettMaria Strømme

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