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A new method for estimating effect size distribution and heritability from genome-wide association summary results

Human Genetics

Dec 15, 2015

Lei ZhangYu-Fang Pei

Abstract

Accurately estimating the distribution and heritability of SNP effects across the genome could help explain the mystery of missing heritability. In this study, we propose a novel statistical method for estimating the distribution and heritability of SNP effects from genome-wide associat...read more

Mentioned in this Paper

Genome-Wide Association Study
Study
Meta Analysis (Statistical Procedure)
Genome
Likelihood Functions
Bone Mineral Content
Candidate Gene Identification
Bone Mineral Density Test
Body Mass Index Procedure
Quantitative Trait, Heritable
2
24
Paper Details
References
  • References24
  • Citations1
123
  • References24
  • Citations1
1

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A new method for estimating effect size distribution and heritability from genome-wide association summary results

Human Genetics

Dec 15, 2015

Lei ZhangYu-Fang Pei

PMID: 26661625

DOI: 10.1007/s00439-015-1621-y

Abstract

Accurately estimating the distribution and heritability of SNP effects across the genome could help explain the mystery of missing heritability. In this study, we propose a novel statistical method for estimating the distribution and heritability of SNP effects from genome-wide associat...read more

Mentioned in this Paper

Genome-Wide Association Study
Study
Meta Analysis (Statistical Procedure)
Genome
Likelihood Functions
Bone Mineral Content
Candidate Gene Identification
Bone Mineral Density Test
Body Mass Index Procedure
Quantitative Trait, Heritable
2
24

Related Papers

American Journal of Human Genetics

A Powerful Pathway-Based Adaptive Test for Genetic Association with Common or Rare Variants

American Journal of Human GeneticsJune 30, 2015
Wei PanPeng Wei
American Journal of Human Genetics

A multi-SNP locus-association method reveals a substantial fraction of the missing heritability

American Journal of Human GeneticsNovember 6, 2012
Georg B EhretZoltán Kutalik
Paper Details
References
  • References24
  • Citations1
123
  • References24
  • Citations1
1
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