A new method for evaluating the bitterness of medicines by semi-continuous measurement of adsorption using a taste sensor

Chemical & Pharmaceutical Bulletin
Takahiro UchidaK Matsuyama

Abstract

We describe a new method for the evaluation of the bitterness of medicines by semi-continuous measurement of adsorption using a multichannel taste sensor or 'electric tongue'. The bitterness of 10 basic medicines was evaluated by both the taste sensor and in human gustatory sensation tests with 11 volunteers. The sensor part of the taste sensor consists of eight electrodes made of lipid/polymer membranes. Three variables were obtained from the taste sensor data: sensor output (S), the change of membrane potential caused by adsorption, corresponding to aftertaste (C), and the ratio C/S. These variables were used to predict an estimated bitterness score in multiple regression analysis. Semi-continuous measurement of C (every 30 s up to 150 s) was adopted as an additional explanatory variable, and the attenuation rate of C was defined as C'. These data were also subjected to multiple regression analysis. The correlation coefficient (r) estimated for the bitterness score predicted by the taste sensor, using C' for channel 2 and C/S for channel 4, and the score obtained by human gustatory sensation, was 0.824. This value was greater than that obtained using C/S for both channels 2 and 4 (0.734). The method described in the present s...Continue Reading

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Citations

Dec 20, 2013·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Michiko YoshidaHideya Kodama
Nov 6, 2003·Chemical & Pharmaceutical Bulletin·Atsu TanigakeTakahiro Uchida
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Tazuko OgawaTakahiro Uchida
Aug 12, 2004·Chemical & Pharmaceutical Bulletin·Toshihiko IshizakaTakahiro Uchida
Dec 4, 2004·Chemical & Pharmaceutical Bulletin·Junji MukaiTakahiro Uchida
Sep 2, 2006·Chemical & Pharmaceutical Bulletin·Emi TokuyamaTakahiro Uchida
Oct 6, 2007·Chemical & Pharmaceutical Bulletin·Toshihiko IshizakaTakahiro Uchida
Mar 5, 2011·Journal of Pharmaceutical Sciences·Nao OnoKaneto Uekama
Nov 26, 2010·International Journal of Pharmaceutics·Katharina WoertzJörg Breitkreutz
Mar 3, 2007·Drug Discovery Today·Vikas AnandPratim Kumar Choudhury
Jan 10, 2004·The Journal of Pharmacy and Pharmacology·Takahiro UchidaAkira Taniguchi
May 26, 2004·International Journal of Pharmaceutics·Hiroyuki SuzukiYoshiharu Machida
Oct 13, 2005·International Journal of Pharmaceutics·Masumi KataokaTakahiro Uchida
Oct 12, 2016·Chemical & Pharmaceutical Bulletin·Yoshihiro HishikawaHirofumi Takeuchi
Sep 26, 2007·The Analyst·Patrycja Ciosek, Wojciech Wróblewski
Dec 23, 2020·Chemistry and Physics of Lipids·Surojit BanerjeeVikas Anand Saharan
Jun 25, 2010·Journal of Agricultural and Food Chemistry·Nobuyuki HayashiHidekazu Ikezaki

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