A new method for the assessment of tissue hemoglobin oxygenation in patients with chronic venous insufficiency

Microvascular Research
J ThumK Alexander

Abstract

Venous incompetence often leads to ulceration of the skin of the lower limb due to a disturbance of skin microcirculation. We investigated 10 healthy subjects and 18 patients with chronic venous insufficiency by means of a fast scanning reflection photometer and determined noninvasively the hemoglobin oxygen saturation (S(HB)) and the relative concentration of hemoglobin (C(HB)) in the skin of the forefoot and at the calf, 10 cm proximal of the inner malleolus during positional changes. In supine position no significant differences were found. During sitting and standing S(HB) dropped and was significantly lower in patients at both locations (calf, standing, patients 22.2 +/- 10.6% vs controls 48.2 +/- 13.5%, P < 0.001). C(HB) increased in patients during standing from 0.71 to 2.13 +/- 0.33 aU (in controls from 0.69 to 1.49 +/- 0.28 aU, P < 0.001). Activation of the muscle pump decreased C(HB) and increased S(HB) in patients and in controls. After the movements were stopped, S(HB) decreased again and fell to the initial low values eight times faster in patients (7.4 +/- 5.3 vs 57.5 +/- 19.6 sec, P < 0.001). C(HB) increased four times faster in patients (7.2 +/- 6.1 vs 29.9 +/- 13.6 sec). In sitting and standing positions hemogl...Continue Reading

Citations

Aug 10, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Yasser Sakr
May 6, 2005·The International Journal of Lower Extremity Wounds·David K Harrison
Aug 25, 2006·The International Journal of Lower Extremity Wounds·M L IabichellaG Mosti
Jan 1, 2001·Nursing Research·D D Wipke-TevisT K Hunt
Aug 5, 2017·Perfusion·Omar MutlakNigel J Standfield
May 25, 2021·Progress in Retinal and Eye Research·Richard F SpaidePeter M Maloca

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