A new method for visualizing pulmonary artery microvasculature using synchrotron radiation pulmonary microangiography: the measurement of pulmonary arterial blood flow velocity in the high pulmonary blood flow rat model

Acta Radiologica
Chiho TokunagaYuji Hiramatsu

Abstract

Increased pulmonary blood flow (PBF) and shear stress may provoke irreversible vascular remodeling, yet invasive visualization of the microvasculature complicates monitoring. A non-invasive imaging methodology would therefore safely provide mechanistic insights into the progression of high PBF-induced vascular remodeling. To establish a novel microvasculature visualization method using synchrotron radiation pulmonary microangiography (SRPA) that can also calculate PBF velocity in vivo. A high PBF rat model was established by making a fistula between the abdominal aorta and inferior vena cava. After eight weeks, SRPA was performed and the dynamic density changes in the right lower pulmonary artery (PA) were calculated by software. SRPA was performed with a HARP (High-Gain Avalanche Rushing amorphous Photoconductor) receiver. PBF velocity was calculated by contrast medium transit time within the PA. All data were presented as mean ± standard error (SE). Student's t-test was used for comparison between the two groups. High dynamic spatial and contrast resolution from SRPA in the PA allowed for clear pulmonary microangiography and accurate detection of higher PBF in the rat model (82.3 ± 8.5 mm/s high-PBF group vs. 46.1 ± 4.3 mm/s ...Continue Reading

References

Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·M D Botney
Nov 1, 2003·European Radiology·G Margaritondo, R Meuli
Dec 29, 2004·Cardiovascular Research·Chen F LamZvonimir S Katusic
Jun 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chen-Fuh LamZvonimir S Katusic
Aug 25, 2011·AJR. American Journal of Roentgenology·Taisuke KonishiYuzuru Sakakibara
Feb 21, 2013·Cardiology in Review·Theofilos M KolettisYasuo Matsumura
Sep 28, 2014·Acta Radiologica·Hiroaki SakamotoYuji Hiramatsu
Mar 10, 2016·Pharmacological Reviews·Anthony P DavenportJanet J Maguire
Jun 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yi Ching ChenJames T Pearson

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imaging technology

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