A new method of quantifying the extent of tissue loss following spinal cord injury in the rat

Experimental Neurology
N J Olby, W F Blakemore

Abstract

Many agents are being tested for their ability to limit the development of secondary tissue damage following trauma to the spinal cord by comparing the extent of trauma-induced tissue destruction between groups of animals receiving different treatments. However, the changes that occur following spinal concussion result in initial swelling of the cord and then progressive shrinkage. It is therefore impossible to determine the preinjury cross-sectional area of cord once it has been damaged, making accurate calculations of the extent of tissue destruction difficult. To overcome this problem, a method for predicting the preinjury cross-sectional area of damaged spinal cord was developed in the rat by establishing correction factors that related the cross-sectional area of a reference transverse section to the area of sections at other points along the cord. This method was used to calculate the volume of tissue destruction in groups of rats 48 h, 4 days, and 4 weeks after photochemically induced cord injury. The results were compared with the volume of tissue destruction obtained when calculated from measured rather than predicted cord areas. One month following photochemically induced injury, the spinal cord had shrunk significant...Continue Reading

Citations

Dec 31, 2011·Translational Stroke Research·Adam R FergusonJessica L Nielson
Apr 5, 2003·Journal of Neurotrauma·Stephen W ScheffJames E Lumpp
Feb 3, 2005·Journal of Neurotrauma·James W GrauRajesh C Miranda
Feb 3, 2005·Journal of Neurotrauma·Aileen J AndersonCarl W Cotman
Oct 11, 2001·American Journal of Veterinary Research·N J OlbyB W Keene
Mar 27, 2007·Behavioural Brain Research·Michelle A HookJames W Grau
Feb 28, 2008·Experimental Neurology·Diana M CittellyJ Regino Perez-Polo
Mar 31, 1999·Journal of Neurotrauma·X Y ChenB T Stokes
Oct 30, 2016·Journal of Medical Biography·Antonis A KousoulisGeorge Androutsos
Apr 5, 2002·Journal of Neuroscience Research·Alexander G RabchevskyStephen W Scheff
Dec 1, 1996·Journal of Neurotrauma·X Y ChenB T Stokes
Jun 30, 2005·Journal of Neurophysiology·B A NorrieM A Gorassini
Dec 24, 2005·The Journal of Comparative Neurology·Kristina A KigerlPhillip G Popovich
Aug 15, 2003·Journal of Neurophysiology·Xiang Yang ChenJonathan R Wolpaw
Apr 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M BilgenP A Narayana
Jan 5, 2002·Experimental Neurology·Charles D MillsClaire E Hulsebosch

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