A new metric of antibiotic class resistance in gram-negative bacilli isolated from hospitalized children.

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Sameer J PatelElaine Larson

Abstract

The purpose of this study was to describe patterns of infection or colonization with antibiotic-resistant gram-negative bacilli (GNB) in hospitalized children utilizing an electronic health record. Tertiary care facility. Pediatric patients 18 years of age or younger hospitalized from January 1, 2006, to December 31, 2008. Children were identified who had (1) at least 1 positive culture for a multidrug-resistant (MDR) GNB, defined as a GNB with resistance to 3 or more antibiotic classes; or (2) additive drug resistance, defined as isolation of more than 1 GNB that collectively as a group demonstrated resistance to 3 or more antibiotic classes over the study period. Differences in clinical characteristics between the 2 groups were ascertained, including history of admissions and transfers, comorbid conditions, receipt of procedures, and antibiotic exposure. Of 56,235 pediatric patients, 46 children were infected or colonized with an MDR GNB, of which 16 were resistant to 3 classes and 30 were resistant to 4 classes. Another 39 patients had positive cultures for GNB that exhibited additive drug resistance. Patients with additive drug resistance were more likely than patients with MDR GNB to have had previous admissions to a long-...Continue Reading

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Oct 28, 2011·Clinical and Translational Science·Mandar ApteElaine Larson

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Citations

Mar 24, 2016·Journal of the Pediatric Infectious Diseases Society·Elias IosifidisEmmanuel Roilides
May 3, 2015·American Journal of Infection Control·Meghan T MurrayElaine L Larson
Sep 10, 2015·Policy, Politics & Nursing Practice·Bevin CohenElaine Larson

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