PMID: 3748061Aug 1, 1986Paper

A new micronucleus test using peripheral blood erythrocytes of the newt Pleurodeles waltl to detect mutagens in fresh-water pollution

Mutation Research
A JayletR Siboulet

Abstract

A model micronucleus test system using peripheral blood erythrocytes from larvae of Pleurodeles waltl is described. The most suitable larval stage for testing chemical treatments was determined. Larvae were reared in water containing one of the 4 compounds: benzo[a]pyrene (BaP), ethyl methanesulphonate (EMS), diethyl sulphate (DES) and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). Response curves as a function of treatment duration over a period of 16 days were plotted for 3 different concentrations of the 4 compounds in order to optimize conditions for a low dose micronucleus test. This model can be used as a monitoring system for the detection of fresh water pollution and can also be employed for clastogen screening of chemical compounds. The test is sensitive, reliable and easy to use.

References

Sep 1, 1978·Mutation Research·R J TrzosJ A Swenberg
Jun 1, 1979·Mutation Research·B E Mackey, J T MacGregor
Sep 1, 1979·Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie·W R Bruce, J A Heddle
May 1, 1978·The Science of the Total Environment·A E PreinC L Poels
Aug 1, 1975·Mutation Research·A D KligermanW M Howell
Jun 9, 1983·Nature·D H Phillips
Sep 1, 1984·Mutation Research·G A Sega
Oct 1, 1982·Mutation Research·U KlieschI D Adler
Aug 1, 1980·Mutation Research·G M AlinkC L Poels

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Citations

Jun 30, 1992·The Science of the Total Environment·M N Wrisberg, M A van der Gaag
Feb 1, 1992·Mutation Research·A O AsitaT Sofuni
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J MartyJ L Rivière
Jul 22, 1998·Mutation Research·M HayashiY Ojima
Dec 18, 2002·Ecotoxicology and Environmental Safety·Mário Pacheco, Maria Ana Santos
Jan 28, 2003·Ecotoxicology and Environmental Safety·M Abul FarahWaseem Ahmad
Jun 12, 2003·Ecotoxicology and Environmental Safety·C Gravato, M A Santos
Aug 1, 1996·Mutation Research·F GodetP Vasseur
Sep 12, 2001·Aquatic Toxicology·C VismaraU Fascio
Dec 29, 1999·Mutation Research·K SaotomeM Hayashi
Nov 13, 2004·Environmental and Molecular Mutagenesis·Ana Zamora-PerezOlivia Torres-Bugarín
Oct 1, 1992·Ecotoxicology and Environmental Safety·J MartyP Lesca
Aug 11, 1991·Ecotoxicology and Environmental Safety·R G Stahl
Mar 12, 2002·Ecotoxicology and Environmental Safety·C Gravato, M A Santos
Jun 7, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·S BarkaA Hamza-Chaffai
Sep 9, 2004·Mutation Research·Awadhesh N Jha
Apr 1, 1992·Ecotoxicology and Environmental Safety·M N WrisbergH Spliid
Oct 5, 2017·Environmental Science and Pollution Research International·Ángel Cruz-EsquivelJose Marrugo-Negrete
Jan 1, 1996·Environmental and Molecular Mutagenesis·S RalphM Vrzoc
Jan 1, 1994·Environmental and Molecular Mutagenesis·M Fernandez, J l'Haridon
Dec 17, 2002·Ecotoxicology and Environmental Safety·V L MariaM A Santos

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