A New Model for Biological Dose Assessment in Cases of Heterogeneous Exposures to Ionizing Radiation

Radiation Research
Mònica PujolJoan-Francesc Barquinero

Abstract

In biological dosimetry by dicentric analysis, an exposure to radiation is considered non-homogeneous if the dicentric cell distribution shows overdispersion with respect to Poisson distribution. Traditionally, when this occurs, all non-homogeneous exposures are considered as partial-body exposures, assuming that there is only a mixture of irradiated and nonirradiated cells. The methods to estimate the dose in the irradiated fraction and the initial fraction of irradiated cells are based on separating which part of the cells without aberrations comes from the nonirradiated or irradiated fractions. In this study we show a new approach based on a mixed Poisson model, which allows for a distinction to be made between partial and heterogeneous exposures. To validate this approach blood samples from two donors, a male and a female, irradiated at different doses, were mixed at a 1:1 proportion to simulate partial and heterogeneous exposures. The results show a good agreement between the observed proportion of male and female cells and the proportion estimated by the model. Additionally, a good agreement was observed between the delivered doses, the initial fraction of cells and the ones estimated by the model. This good agreement was...Continue Reading

References

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Aug 13, 2011·Radiation Protection Dosimetry·Mónica PujolJoan-Francesc Barquinero
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Jun 13, 2015·Radiation Protection Dosimetry·Manuel HiguerasKai Rothkamm

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Citations

Jun 28, 2016·Radiation Protection Dosimetry·Ioanna KarachristouGeorgia I Terzoudi
Apr 23, 2020·PloS One·Monica Pujol-CanadellDavid J Brenner
Jan 10, 2021·Scientific Reports·M H YashavarddhanSandeep Kumar Shukla
Jun 18, 2021·International Journal of Radiation Biology·David EndesfelderAndrzej Wojcik
Oct 28, 2021·International Journal of Radiation Biology·Juan S LópezJoan F Barquinero

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