A new model for predicting acute mucosal toxicity in head-and-neck cancer patients undergoing radiotherapy with altered schedules

International Journal of Radiation Oncology, Biology, Physics
Lidia StrigariMarcello Benassi

Abstract

One of the worst radiation-induced acute effects in treating head-and-neck (HN) cancer is grade 3 or higher acute (oral and pharyngeal) mucosal toxicity (AMT), caused by the killing/depletion of mucosa cells. Here we aim to testing a predictive model of the AMT in HN cancer patients receiving different radiotherapy schedules. Various radiotherapeutic schedules have been reviewed and classified as tolerable or intolerable based on AMT severity. A modified normal tissue complication probability (NTCP) model has been investigated to describe AMT data in radiotherapy regimens, both conventional and altered in dose and overall treatment time (OTT). We tested the hypothesis that such a model could also be applied to identify intolerable treatment and to predict AMT. This AMT NTCP model has been compared with other published predictive models to identify schedules that are either tolerable or intolerable. The area under the curve (AUC) was calculated for all models, assuming treatment tolerance as the gold standard. The correlation between AMT and the predicted toxicity rate was assessed by a Pearson correlation test. The AMT NTCP model was able to distinguish between acceptable and intolerable schedules among the data available for t...Continue Reading

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Nov 8, 2008·International Journal of Radiation Oncology, Biology, Physics·Lidia StrigariMarcello Benassi
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Citations

Oct 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sara MeadeAndrew Hartley
Mar 24, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·Alan E Nahum
Nov 28, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·John D FenwickW Philip M Mayles
Oct 11, 2015·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·D HenatschR J Stokroos
Jun 27, 2020·International Journal of Radiation Biology·Martín Parga-PazosJuan Pardo-Montero
Oct 15, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L ProvenzanoS J González
Nov 10, 2018·Oral Oncology·N Patrik Brodin, Wolfgang A Tomé
Apr 20, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M SharabianiC Hurkmans
Jul 22, 2021·International Journal of Particle Therapy·Johannes A LangendijkEwoud Schuit

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