A new model for tethered cord syndrome: a biochemical, electrophysiological, and electron microscopic study

Pediatric Neurosurgery
A KoçakA Colak

Abstract

In order to investigate the pathophysiology of the tethered cord syndrome, a few experimental models have been developed and used previously. In this study, the authors present a new experimental model to investigate the biochemical, electrophysiological, and histopathological changes in the tethered spinal cord syndrome. A model was produced in guinea pigs using an application of cyanoacrylate to fixate the filum terminale and the surrounding tissue to the dorsal aspect of the sacrum following 5-gram stretching of the spinal cord. The experiments were performed on 40 animals divided into two groups. The responses to tethering were evaluated with hypoxanthine and lipid peroxidation, somatosensory and motor evoked potentials, and transmission electron microscope examination. The hypoxanthine and lipid peroxidation levels significantly increased, indicating an ischemic injury (p < 0.01). The average hypoxanthine level in the control group was 478.8 +/- 68.8 nmol/g wet tissue, while it was 651.2 +/- 71.5 nmol/g in the tethered cord group. The lipid peroxidation level in group I was 64.0 +/- 5.7 nmol/g wet tissue, whereas it was 84.0 +/- 4.7 nmol/g in group II. In the tethered cord group, the latencies of the somatosensory and moto...Continue Reading

Citations

Sep 3, 2011·Journal of Neurosurgery. Pediatrics·Sumit ThakarAlangar S Hegde
Jul 20, 2006·Journal of Neurosurgery·James M Drake
Jun 17, 2006·Journal of Neurosurgery. Spine·Andrew W GrandeCharles Kuntz
Sep 18, 2010·Surgical Neurology International·Fraser C HendersonEdward Benzel
Oct 18, 2014·Journal of Neurosurgery. Pediatrics·Kimberly A FosterStephanie Greene
Oct 25, 2012·The Spine Journal : Official Journal of the North American Spine Society·Tri C LeCarlos A Bagley
Apr 6, 2007·Pediatric Neurosurgery·Sean M Lew, Karl F Kothbauer
Mar 16, 2017·Journal of Neurosurgery. Spine·Ji Yeoun LeeKyu-Chang Wang
Oct 4, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Gesa CohrsFriederike Knerlich-Lukoschus

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