A new model of experimental allergic rhinitis using Japanese cedar pollen in guinea pigs

Japanese Journal of Pharmacology
Takeshi NabeShigekatsu Kohno

Abstract

In the majority of the models of experimental allergic rhinitis, antigen challenge has been performed by single topical instillation or perfusion with the solution. The present study was performed to establish a good model using Japanese cedar pollen, which is able to repeatedly induce allergy restricted to the upper airway. Guinea pigs sensitized with the pollen extracts were subjected to quantitative and repeated inhaling of the pollen with a devised apparatus. Following the respective challenges, the nasal cavity was washed with a new technique: Washing with physiologic saline was performed from one nostril to the other one, the latter of which was kept under slightly reduced pressure. When the animal was subjected to cedar pollen inhalation, almost all the pollens inhaled were located in the upper airway. At the 5th inhalation, nasal cavity lavage revealed that both albumin leakage and histamine release into the nasal cavity were increased at maximum levels in 1 hr (respectively 2 mg and 3 ng/animal); and at the same time, a considerable number of leukocytes, especially eosinophils, were found migrating into the nasal cavity for at least 10 hr. The present methods can permit various analyses of allergic rhinitis and the ass...Continue Reading

Citations

Apr 9, 2002·European Journal of Pharmacology·Masashi YamasakiShigekatsu Kohno
May 24, 2011·Prostaglandins & Other Lipid Mediators·Takeshi NabeShigekatsu Kohno
Jan 29, 2016·TheScientificWorldJournal·Hélène SénéchalJean-Pierre Sutra
Jul 17, 2008·International Immunopharmacology·Prashant C BahekarRajamannar Thennati
Sep 10, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T NabeS Kohno
Nov 25, 2004·Prostaglandins & Other Lipid Mediators·Yasutomo NakanishiShigekatsu Kohno
Aug 31, 2006·Prostaglandins & Other Lipid Mediators·Yoshiki TanakaShigekatsu Kohno
Oct 24, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Takeshi NabeShigekatsu Kohno
Feb 26, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Hiromi Ogita-NakanishiShigekatsu Kohno
Jul 17, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ming-Tse KoHong-Yo Kang
Dec 4, 2003·Biological & Pharmaceutical Bulletin·Yoshitaka FukushimaShigekatsu Kohno
Jan 23, 2004·Journal of Pharmacological Sciences·Nobuaki MizutaniShigekatsu Kohno
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C KobayashiM Sakaguchi
Jun 24, 2011·Phytotherapy Research : PTR·Nobuaki MizutaniShigekatsu Kohno
Apr 2, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshiaki Makino
Nov 8, 2007·Journal of Pharmacological Sciences·Nobuaki MizutaniShigekatsu Kohno
Dec 15, 2007·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Nobuaki MizutaniShigekatsu Kohno
Jul 6, 2005·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takeshi NabeShigekatsu Kohno
Aug 5, 2005·Journal of Pharmacological Sciences·Takeshi NabeShigekatsu Kohno
May 12, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mustafa SagitMehmet Yasar

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