A new model of glaucoma filtering surgery in the rat

Journal of Glaucoma
M B SherwoodD A Samuelson

Abstract

The most common reason for long-term failure of glaucoma filtering surgery (GFS) is scarring of the external filtering "bleb" tissues. The identification of the factors that mediate this process, as well as the development and initial testing of new therapies to limit scarring is enhanced by the use of appropriate animal models. The standard animal model for studying GFS is the rabbit but newer investigative tools that examine changes induced in biologic systems at a genetic level have made development of a rat model desirable. Glaucoma filtering surgery was performed on 20 Sprague-Dawley rats by introducing a 30-gauge silicone cannula through a penetrating scleral tunnel, under a limbal-based conjunctival flap and suturing the conjunctiva closed. Identical GFS was performed on 3 additional rats, which underwent histologic evaluation at days 2, 5, and 11, following surgery.Fistulizing surgery was also performed on 6 Sprague-Dawley rats, for comparison, by creating a full-thickness needle sclerostomy under a limbal-based conjunctival flap and suturing the conjunctiva closed. Following the cannula GFS, well-elevated filtering blebs formed and these gradually failed over the course of 8 to 13 days. Needle tract sclerostomy filteri...Continue Reading

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Citations

Jun 23, 2009·Survey of Ophthalmology·Xuyang LiuPaul L Kaufman
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Mi Sun SungSang Woo Park
Dec 12, 2019·Eye·David L Williams
Jan 8, 2021·Veterinary Ophthalmology·András M KomáromyShin Ae Park

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