PMID: 6621372Apr 1, 1983Paper

A new model of human VLDL metabolism based on simultaneous studies of its APOB and triglyceride

Metabolism: Clinical and Experimental
G Steiner, M F Reardon

Abstract

Previous studies which separately examined the behavior of the B apolipoprotein and of the triglyceride of VLDL had raised the possibility that each was metabolized in a different manner. The present studies have explored this possibility by simultaneously studying each of these VLDL constituents in thirteen humans. 125I-labeled Sf 60-400 lipoproteins were injected. The fate of their apo B (a reflection of the metabolism of the lipoprotein particle) was followed in this, and in the smaller Sf 12-60 lipoproteins. In everyone, the larger particle was catabolized to the smaller one. Furthermore, the smaller particle was derived exclusively from the larger one. The behavior of the lipoproteins' triglyceride was examined by following the specific activity of 3H-triglyceride which had been endogenously labelled by injecting 2-3H-glycerol. Some of the larger lipoproteins' triglyceride appeared in the smaller particles. However, in contrast to the apo B, the triglyceride in the smaller particle was not derived exclusively from that in the larger particle. In eleven subjects, the triglyceride specific activity curves above demonstrated that some of the triglyceride entered the smaller circulating particle from a source other than the la...Continue Reading

References

Dec 1, 1977·Metabolism: Clinical and Experimental·D StrejaG Steiner
Mar 1, 1978·The Journal of Clinical Investigation·M F ReardonP J Nestel
Apr 1, 1978·The Journal of Clinical Investigation·A SnidermanB Teng
Dec 20, 1973·Biochimica Et Biophysica Acta·S EisenbergF T Lindgren
May 1, 1982·Metabolism: Clinical and Experimental·M F ReardonG Steiner
Aug 1, 1981·Canadian Journal of Biochemistry·G Steiner, W K Ilse
Jan 20, 1943·The Journal of General Physiology·D B ZilversmitM C Fishler

Citations

Sep 18, 1998·Diabetes Research and Clinical Practice·G Steiner
May 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T Sane, E A Nikkilä
Jul 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M PoapstG Steiner
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·N EliasG Schonfeld
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Martin AdielsJan Borén

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