A new model of tethered cord syndrome produced by slow traction

Scientific Reports
Sheng-Li HuangBin-Shang Lan

Abstract

The development of a suitable animal model is important for clarifying the pathogenesis of tethered cord syndrome (TCS). This study was undertaken to develop a new animal model for investigating the pathogenesis and therapeutic strategies for TCS. A traction device, a filum terminale tractor, was designed exclusively for this experiment. A TCS model was produced in cats using the tractor to fixate the filum terminale to the dorsal aspect of the second sacrum. The responses to tethering were evaluated by electron microscopy and electromyography for detection of somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) at designated time points. Progressive swaying gait and lameness in clinical performance were observed with cord traction. Histopathological examination revealed an association between the increasing traction in the spinal cord and the increase in impaired nerve cells. No changes of SEPs and MEPs were detected in the untethered cats, while the latencies of SEPs and MEPs significantly increased in the tethered cats. The TCS model established in this study is simple and reproducible, in which varying degrees of tension could be applied to the neural elements.

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Citations

May 23, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Murat GeyikCahit Kural
Jan 25, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Marie BerthelotYves Maugars
Sep 14, 2017·Neuroreport·Jing-Jie LiuSheng-Li Huang
Jul 22, 2016·Medicine·Jing-Jie LiuSheng-Li Huang
Oct 4, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Gesa CohrsFriederike Knerlich-Lukoschus
Dec 5, 2020·The International Journal of Neuroscience·Yan SunJiangang Zeng
May 10, 2019·The Journal of Surgical Research·Marc OriaJose L Peiro

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