A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase-deficient individuals.

Archives of Women's Mental Health
Harish Thippeswamy, William Davies

Abstract

Postpartum mood disorders develop shortly after childbirth in a significant proportion of women. These conditions are associated with a range of symptoms including abnormally high or low mood, irritability, cognitive disorganisation, disrupted sleep, hallucinations/delusions, and occasionally suicidal or infanticidal ideation; if not treated promptly, they can substantially impact upon the mother's health, mother-infant bonding, and family dynamics. The biological precipitants of such disorders remain unclear, although large changes in maternal immune and hormonal physiology following childbirth are likely to play a role. Pharmacological therapies for postpartum mood disorders can be effective, but may be associated with side effects, concerns relating to breastfeeding, and teratogenicity risks when used prophylactically. Furthermore, most of the drugs that are used to treat postpartum mood disorders are the same ones that are used to treat mood episodes during non-postpartum periods. A better understanding of the biological factors predisposing to postpartum mood disorders would allow for rational drug development, and the identification of predictive biomarkers to ensure that 'at risk' mothers receive earlier and more effecti...Continue Reading

References

Aug 18, 1999·Clinical Genetics·J MilunskyA Milunsky
May 24, 2000·Brain Research·D A JohnsonT J Maher
Sep 18, 2002·Journal of Cell Science·Martha C Nowycky, Andrew P Thomas
Sep 11, 2003·Current Opinion in Neurobiology·Hugh R Matthews, Johannes Reisert
Nov 11, 2003·Cell Communication and Signaling : CCS·Alain LombetBernard Perbal
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Noriko TagawaNobuyuki Amino
Nov 25, 2004·Endocrine Reviews·M J ReedB V L Potter
Apr 9, 2005·Human Reproduction Update·Annechien BoumanMarijke M Faas
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susannah J StanwayR Charles Coombes
Jun 15, 2006·Journal of Dairy Science·K KimuraJ P Goff
Nov 1, 2006·Current Pharmaceutical Design·R Lane BrownJeffrey W Karpen
Nov 23, 2006·Current Opinion in Pharmacology·Andrea L O Hebb, Harold A Robertson
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Claire R QuilterNabeel A Affara
Nov 30, 2007·American Journal of Physical Anthropology·Robert D Martin
Nov 4, 2008·Nature Cell Biology·Thomas F J WagnerJohannes Oberwinkler
Mar 3, 2009·Biological Psychiatry·William DaviesLawrence S Wilkinson
Apr 18, 2009·Cell Adhesion & Migration·Viviana Vallacchi, Monica Rodolfo
Sep 17, 2009·The American Journal of Psychiatry·Pamela Belmonte MahonJames B Potash
Feb 24, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Veerle BerginkHemmo A Drexhage
Dec 23, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Simon TrentWilliam Davies
Apr 6, 2012·Trends in Molecular Medicine·William Davies
Dec 29, 2012·Biological Psychiatry·Veerle BerginkHemmo A Drexhage
Jan 4, 2013·Molecular Brain·Xiang-ming Zha
Feb 14, 2013·PloS One·Caroline FlegelGünter Gisselmann
Mar 21, 2013·Schizophrenia Bulletin·Katharina Domschke
May 9, 2013·Bipolar Disorders·Emma Robertson BlackmoreIan Jones
Nov 15, 2013·American Journal of Physiology. Cell Physiology·Brandie M CrossRajini Rao
Feb 18, 2014·British Journal of Pharmacology·C V Perani, D A Slattery
Mar 7, 2014·European Archives of Psychiatry and Clinical Neuroscience·Daniela KrauseMarkus J Schwarz
May 21, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William DaviesLawrence S Wilkinson
Jul 20, 2014·Hormones and Behavior·Rebeca Corona, Frédéric Lévy
Nov 21, 2014·Progress in Brain Research·Bart R LubbersMichel C van den Oever
Nov 21, 2014·Biology of Reproduction·Jeffrey T ThornePhyllis C Leppert
Feb 24, 2015·Journal of Biomechanics·Fiona C LoftusAnatoly Shmygol
Jul 28, 2015·Endocrine Reviews·Jonathan W MuellerPaul A Foster

❮ Previous
Next ❯

Citations

Mar 19, 2021·Frontiers in Cell and Developmental Biology·Katharina Held, Balázs István Tóth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
Shelley DoucetEmma Robertson Blackmore
Southern Medical Journal
J L Daw
© 2021 Meta ULC. All rights reserved