Abstract
The whole plant of Marrubium vulgare L. afforded a new terpenoid, characterised as p-menthane-5,6-dihydroxy-3-carboxylic acid (1), which has been designated as marrubic acid. Its structure has been elucidated on the basis of spectral and chemical analyses. The compound (1) also exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 40.16%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 35.06%, and alkaline phosphatase (ALP) by 30.51%. On the other hand, total protein (TP) levels were increased by 34.07%, as compared to the standard drug silymarin, which decreased SGOT by 53.04%, SGPT by 55.96%, ALP by 35.87% and increased TP levels by 59.59%. These biochemical observations were also supplemented by histopathological examinations of liver sections.
References
May 15, 2001·Clinical and Experimental Hypertension : CHE·S El BardaiN Morel
Jun 8, 2001·Journal of Ethnopharmacology·B AhmedS A Khan
Feb 19, 2002·Journal of Ethnopharmacology·Sevser SahpazFrancois Bailleul
Jun 7, 2002·Natural Product Letters·Sevser SahpazFrançois Bailleul
Feb 5, 2003·Planta medica·Sanae El BardaiJoëlle Quetin-Leclercq
Jul 16, 2003·Journal of Ethnopharmacology·Bahar AhmedAbu B Siddiqui
Nov 1, 1954·Journal of Clinical Pathology·P R KIND, E J KING
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Aug 1, 1964·Journal of Pharmaceutical Sciences·H J NICHOLAS
Nov 5, 2003·British Journal of Pharmacology·Sanae El-BardaiNicole Morel
Nov 24, 2004·Clinical and Experimental Hypertension : CHE·Sanae El BardaiNicole Morel
Apr 26, 2005·Il Farmaco·C Meyre-SilvaV Cechinel-Filho
Jul 19, 2006·Journal of Ethnopharmacology·Hellen K StulzerValfredo Schlemper
Sep 1, 1996·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·V SchlemperV Cechinel Filho
Apr 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M M de SouzaV Schlemper
Citations
Jul 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milica AćimovićTijana Zeremski
Dec 12, 2020·Heliyon·Jaadan HayatSaadia Belmalha
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ryan D Rattray, Ben-Erik Van Wyk