A new mouse avatar model of non-small cell lung cancer

Frontiers in Oncology
Maria Veronica RussoSilvano Bosari

Abstract

Lung cancer remains the leading cause of tumor-related deaths, despite advances in the understanding of the disease pathogenesis and in its clinical treatment. It is crucial to develop novel technologies to discover disease biomarkers and predict individual therapy response. We established 48 patients-derived tumor xenografts (PDTXs) implanted in the subrenal capsule of immunodeficient mice using thin, precision-cut tumor tissue slices, derived from five patients affected by non-small cell lung cancer. Twenty-six tissue slices were immediately processed and implanted at sample recovery [patients-derived tumor xenografts derived from fresh tissue (dPDTX)], whereas the remaining sections were cultured on specific organotypic supports at 37°C and 5% CO2 for 24 h before grafting [patients-derived tumor xenografts derived from cultured tissue (cPDTX)]. At sacrifice, xenografts tissue morphology, proliferation (Ki67), and histotype markers were analyzed. Oncogenic miRNAs profiles were assessed in PDTXs, human tumors, and serum from one patient. Xenografts retained the original cancer features and there were no differences between dPDTXs and cPDTXs. Squamous cell carcinoma (SCC) xenografts showed a higher engraftment rate than adenoca...Continue Reading

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Citations

Sep 4, 2020·Diagnostics·Anca OnaciuIoana Berindan-Neagoe
Jun 18, 2020·Transplantation Direct·Alessandro PalleschiValentina Vaira
Apr 10, 2021·Nature Communications·Andrea FariniYvan Torrente

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Methods Mentioned

BETA
surgical resection
xenografts
xenograft
sedation
DNA-Chip

Software Mentioned

GeNorm
Prism
Photoshop
GraphPad
Chip Analyser
DNA

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