PMID: 6974693Jan 1, 1981Paper

A new mouse cell-surface antigen (Ly-m18) defined by a monoclonal antibody

Immunogenetics
S KimuraU Hämmerling

Abstract

Spleen cells from C3H/An mice immunized with spleen cells of C57BL/6-H-2k mice were fused with myeloma cell line NS.1. One established hybrid cell line continuously secreted antibody that recognized a new surface antigen provisionally called Ly-m18. The new alloantigen is expressed on 90 percent of thymus cells, 55 percent of spleen cells, and 45 percent of either lymph-node or bone-marrow cells. It is also expressed on cells derived from brain, kidney, and liver. Fifty percent of either peripheral T or B cells express the Ly-m18 antigen, and some tumor cell lines with T, B, pre-B or stem cell characteristics are Ly-m18 (+). The strain distribution pattern distinguishes Ly-m18 antigen from all other murine lymphocyte alloantigens. The typing data of two sets of CXB and AKXL recombinant inbred strains indicate that the Ly-m18 gene is linked to the Ltw-2 locus which has not yet been assigned to a chromosome.

References

Jan 1, 1979·Advances in Immunology·I F McKenzie, T Potter
Aug 1, 1976·Biochemical Genetics·J D MishkinW J Mellman
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·B A TaylorD D Myers
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Jan 1, 1980·Immunogenetics·N TadaU Hämmerling
Feb 1, 1981·Journal of Immunogenetics·T A PotterM C Cherry

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Citations

Dec 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M NishimuraH Hiai
Jan 1, 1987·Immunogenetics·H C MorseU Hämmerling
Jan 1, 1987·Immunogenetics·K J HasenkrugJ H Stimpfling
Jan 1, 1986·Immunogenetics·K J Hasenkrug, J H Stimpfling
Dec 1, 1992·Molecular Immunology·K J HasenkrugS G Nathenson
Nov 1, 1988·Immunology Today·K L Holmes, H C Morse
Jan 1, 1983·Immunology Today·I F McKenzie, H Zola
Nov 1, 1986·European Journal of Immunology·Y AiharaJ Klein

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