A new mutation at the period locus of Drosophila melanogaster with some novel effects on circadian rhythms

Journal of Neurogenetics
M Hamblen-CoyleJ C Hall

Abstract

A new period mutation has been induced and characterized in D. melanogaster. It causes flies to be apparently arrhythmic in tests of locomotor activity and thus is superficially similar to the original per01 mutant. Yet, the new "zero" allele, per04, has some novel properties and effects: Behaviorally, per04 adults often exhibit weak, long-period rhythms of locomotor activity in constant darkness; this low-frequency rhythmicity usually was not obvious in the analog behavioral records but was readily revealed by spectral analyses. These treatments of the data also extracted hidden high-frequency (ultradian) rhythms in many of the behavioral records, of the type associated with per01 and other per-nulls. The wide range of periodicities exhibited by different per04-expressing flies implies the expression of multiple oscillatory modes by this mutant. The new mutation also leads to a tendency for flies to be hyperactive during activity monitoring and is thus dissimilar to the other arrhythmic variants in the per gene but similar to the effects of a deletion of the locus. During light:dark cycling, per04 adults once more behave differently from other per0's and in fact tend to resemble wild-type flies in these conditions. The new mut...Continue Reading

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Citations

Sep 1, 1990·Behavior Genetics·C P KyriacouJ C Hall
Mar 1, 1990·Behavior Genetics·C P Kyriacou
Nov 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F W Turek, D E Kolker
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