A new natural angelica polysaccharide based colon-specific drug delivery system

Journal of Pharmaceutical Sciences
Siyuan ZhouQibing Mei

Abstract

Colon-specific drug delivery systems are clinically necessary to treat colon diseases locally while minimizing systemic side effects. In this study, we extracted angelica polysaccharide from fresh roots of Angelica sinensis Diels and analyzed the monosaccharide components. With succinate as a cross-linker and angelica polysaccharide as a drug carrier, a dexamethasone-polysaccharide conjugate was synthesized. The amount of dexamethasone (Dex) loaded in the dexamethasone-polysaccharide conjugate was 14.13/100 mg. The newly synthesized dexamethasone-polysaccharide conjugate was found to greatly reduce systemic absorption of Dex and effectively deliver Dex to the large intestine. When dexamethasone-polysaccharide conjugate was used to treat TNBS-induced ulcerative colitis in rats by gavage, the ulcerative area of the colon and the colonic myeloperoxidase (MPO) activity was reduced in a dose-dependent manner. There was no effects on spleen weight, thymus weight, or peripheral blood lymphocyte count (0.25 micromol kg(-1) day(-1)). These results indicate that the dexamethasone-polysaccharide conjugate has a therapeutic effect on TNBS-induced ulcerative colitis in rats, while simultaneously reducing the systemic immunosuppression cause...Continue Reading

References

Jan 1, 1994·The American Journal of Chinese Medicine·Y M ChoyP K Pang
Aug 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·C S Leopold, D R Friend
Mar 21, 2000·International Reviews of Immunology·M NeurathW Strober
Jul 27, 2001·International Journal of Pharmaceutics·V R Sinha, R Kumria
Mar 16, 2005·Analytical Biochemistry·Tatsuya MasukoYuan C Lee
Nov 8, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xingbin YangQibing Mei
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Song-Qi GaoJindrich Kopecek
Jun 23, 2006·International Journal of Pharmaceutics·O ChambinY Pourcelot
Jul 15, 2006·International Journal of Biological Macromolecules·Tiehong YangQibing Mei
Sep 5, 2006·Expert Opinion on Drug Delivery·Andrea GazzanigaLucia Zema
Nov 30, 2006·The Journal of Pharmacy and Pharmacology·Hrushikesh B AgasheN K Jain
Apr 12, 2007·Critical Reviews in Therapeutic Drug Carrier Systems·Anekant JainSanjay K Jain

❮ Previous
Next ❯

Citations

Aug 20, 2011·Chinese Medicine·Wen-Wan Chao, Bi-Fong Lin
Nov 2, 2018·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Yasamin Davatgaran TaghipourMohammad Abdollahi
Jan 3, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Yu ZhangKai-Ping Wang
Jun 7, 2021·International Journal of Biological Macromolecules·Jijuan NaiHuagang Sheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.