A new natural angelica polysaccharide based colon-specific drug delivery system

Journal of Pharmaceutical Sciences
Siyuan ZhouQibing Mei


Colon-specific drug delivery systems are clinically necessary to treat colon diseases locally while minimizing systemic side effects. In this study, we extracted angelica polysaccharide from fresh roots of Angelica sinensis Diels and analyzed the monosaccharide components. With succinate as a cross-linker and angelica polysaccharide as a drug carrier, a dexamethasone-polysaccharide conjugate was synthesized. The amount of dexamethasone (Dex) loaded in the dexamethasone-polysaccharide conjugate was 14.13/100 mg. The newly synthesized dexamethasone-polysaccharide conjugate was found to greatly reduce systemic absorption of Dex and effectively deliver Dex to the large intestine. When dexamethasone-polysaccharide conjugate was used to treat TNBS-induced ulcerative colitis in rats by gavage, the ulcerative area of the colon and the colonic myeloperoxidase (MPO) activity was reduced in a dose-dependent manner. There was no effects on spleen weight, thymus weight, or peripheral blood lymphocyte count (0.25 micromol kg(-1) day(-1)). These results indicate that the dexamethasone-polysaccharide conjugate has a therapeutic effect on TNBS-induced ulcerative colitis in rats, while simultaneously reducing the systemic immunosuppression cause...Continue Reading


Jan 1, 1994·The American Journal of Chinese Medicine·Y M ChoyP K Pang
Aug 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·C S Leopold, D R Friend
Mar 21, 2000·International Reviews of Immunology·M NeurathW Strober
Jul 27, 2001·International Journal of Pharmaceutics·V R Sinha, R Kumria
Mar 16, 2005·Analytical Biochemistry·Tatsuya MasukoYuan C Lee
Nov 8, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xingbin YangQibing Mei
Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Song-Qi GaoJindrich Kopecek
Jun 23, 2006·International Journal of Pharmaceutics·O ChambinY Pourcelot
Jul 15, 2006·International Journal of Biological Macromolecules·Tiehong YangQibing Mei
Sep 5, 2006·Expert Opinion on Drug Delivery·Andrea GazzanigaLucia Zema
Nov 30, 2006·The Journal of Pharmacy and Pharmacology·Hrushikesh B AgasheN K Jain
Apr 12, 2007·Critical Reviews in Therapeutic Drug Carrier Systems·Anekant JainSanjay K Jain

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