PMID: 9430794Feb 7, 1998Paper

A new nausea model in humans produces mild nausea without electrogastrogram and vasopressin changes

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
B D KiernanR W McCallum

Abstract

The standard human vection model utilized for nausea has been an optokinetic drum. This model may be difficult to extrapolate to the usual clinical setting. Our goals were to develop an experimental model which could induce low grade nausea in humans and to determine the relationship between mild nausea and changes in the electrogastrogram and plasma vasopressin concentrations. Twenty-one volunteers (11 males, mean age: 37 years) participated. At baseline and throughout the study the electrogastrogram was monitored, blood was drawn for vasopressin assay and symptoms of nausea, dizziness and headache were rated on a 0-10-point scale. Subjects were semireclined in a darkened room while viewing moving bars of light rotating at a rate of 85 degrees s-1. Subjects were asked to rate their proneness to motion sickness and their current level of anxiety at baseline. Eight subjects developed mild to moderate (mean: 3.6) nausea during vection. Symptoms of nausea were correlated with a reported history of motion sickness (r = 0.49, P < 0.05) but not with anxiety (r = 0.14, P = 0.54). Degrees of nausea correlated with degrees of dizziness (r = 0.47, P < 0.05) but not with headache (r = 0.29, P = 0.14). Subjects who developed mild nausea we...Continue Reading

Citations

Oct 6, 2006·Experimental Brain Research·James R Lackner, Paul Dizio
May 10, 2002·Journal of Gastroenterology and Hepatology·David WingateAndré Smout
Jul 28, 2016·Autonomic Neuroscience : Basic & Clinical·Carey D Balaban, Bill J Yates
Feb 7, 2017·Journal of Neurogastroenterology and Motility·Irene SarosiekRichard W McCallum
Sep 9, 2019·Digestive Diseases and Sciences·Phillip SnodgrassRichard W McCallum
Jul 6, 2020·Journal of Vestibular Research : Equilibrium & Orientation·Justin Maximilian Mittelstaedt
May 11, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G SongR W McCallum

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