A new nomogram for estimating survival in patients with brain metastases secondary to colorectal cancer

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Filippo PietrantonioRosalba Miceli

Abstract

The prognosis of brain metastases (BM) in colorectal cancer (CRC) is extremely poor, but the incidence is increasing. The performance of existing prognostic classifications such as recursive partitioning analysis (RPA) and graded prognostic assessment (GPA) has never been evaluated in this specific setting. Moreover, the development of nomograms for estimating survival in such patients could be extremely helpful for treating physicians. Between 2000 and 2013, data from 227 patients with BM from CRC were collected at 8 Italian institutions. Overall survival (OS) was estimated with the Kaplan-Meier method and statistical comparison between curves was performed using the log-rank test. The discriminative ability for OS of RPA and GPA was assessed by the Harrell C-index from univariable Cox models. Putative prognostic factors for OS were also studied by multivariable Cox analysis, using the Harrell C index to evaluate the model discriminative ability. After a backward variable selection, a nomogram was developed to predict median survival time from individual patient- and tumor-related characteristics. The nomogram was externally validated on an independent series. After a median follow-up of 59 months, fifty percent of patients we...Continue Reading

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Citations

Feb 26, 2016·Clinical Neurology and Neurosurgery·Carsten NiederAnca L Grosu
May 28, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Valerio NardoneLuigi Pirtoli
Sep 24, 2020·International Journal of Colorectal Disease·Mingshuang TangLihua Wang
Dec 16, 2018·BMC Medical Informatics and Decision Making·Ellen G EngelhardtVeerle M H Coupé
Nov 7, 2019·Scandinavian Journal of Gastroenterology·Jichuan QuanXishan Wang
Jul 10, 2020·Neuro-oncology Advances·Pragnan KancharlaTed K Yanagihara
Feb 28, 2020·World Journal of Gastrointestinal Oncology·Ji-Chuan QuanXi-Shan Wang
Feb 19, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pauline RoussilleDavid Tougeron

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