Abstract
Traditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dyskinetic state. ChIs integrate numerous neurotransmitter signals using intrinsic glutamate, serotonin, and DA receptors and convey the appropriate transmission onto nearby muscarinic and nicotinic ACh receptors to produce movement. In PD, severe DA depletion causes abnormal rises in ChI activity which promote striatal signaling to attenuate normal movement. When treating PD with L-DOPA, hyperkinetic side effects, or LID, develop due to increased striatal DA; however, the role of ChIs and ACh transmission, until recently has been unclear. Fortunately, new technology and pharmacological agents have facilitated understanding of ChI function and ACh signaling in the context of LID, thus offering new opportunities to modify existing and discover future therapeutic strategies in mov...Continue Reading
Citations
Sep 20, 2018·The European Journal of Neuroscience·Samira ZtaouMarianne Amalric
Apr 12, 2019·Biomolecules·Fabio Del BelloWilma Quaglia
Apr 18, 2020·The European Journal of Neuroscience·Cecilia Tubert, Mario Gustavo Murer
Mar 7, 2020·Acta Pharmacologica Sinica·Changliang Liu
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Xiaoran LiRong Wang
Aug 14, 2020·CNS Drugs·Paulina Gonzalez-LatapiSusan H Fox
Oct 31, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Stanley N Caroff
Nov 22, 2020·Journal of Neurochemistry·Christine N Metz, Valentin A Pavlov
Jan 15, 2021·Cerebral Cortex·Kelly SmartAnsel T Hillmer
Jan 19, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Chiara MelisMichelle E Ehrlich
Mar 30, 2021·Frontiers in Neuroscience·Kai YangTaolei Sun
Mar 3, 2019·Neurochemistry International·Samira Ztaou, Marianne Amalric
Apr 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Stanley N CaroffE Cabrina Campbell
Nov 5, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Hemanth R NelvagalJonathan D Cooper
Sep 24, 2021·Communications Biology·Lauren MalaveAndreas H Kottmann