Abstract
No universal classification method for intrahepatic cholangiocarcinoma (IHCC) has been reported based on the embryological origin of biliary epithelial cells. The aim of this study was to classify IHCC according to protein expression levels of somatostatin receptor 2 (SSTR2) and b-cell leukemia/lymphoma 2 (Bcl2) and to elucidate the clinicopathological features of each group. Fifty-two IHCC patients who underwent hepatic resection were enrolled in this study. Protein expression levels of SSTR2 and Bcl2 were examined using immunohistochemistry. Clinicopathological factors were compared between the three groups and prognostic factors were investigated. The patients were divided into three groups: SSTR2 positive and Bcl2 negative (p-Group H, n = 21), SSTR2 negative and Bcl2 positive (p-Group P, n = 14), and the indeterminate group (p-Group U, n = 17) for cases where SSTR2 and Bcl2 were both positive or both negative. All p-Group P cases displayed curability A or B. The 5-year survival rates of p-Group H and U patients were worse than those in p-Group P. p-Group H had higher T-factor, clinical stage, and incidence of periductal infiltration than p-Group P. This method could be used to classify IHCC into peripheral and perihilar typ...Continue Reading
References
Mar 1, 1989·Journal of Hepatology·T TeradaY Nakanuma
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G A MathisA E Sirica
May 1, 1997·The American Journal of Physiology·G AlpiniG D LeSage
May 12, 1998·The American Journal of Physiology·G AlpiniN F LaRusso
Oct 2, 1998·The American Journal of Physiology·A CelliN F LaRusso
May 18, 1999·The American Journal of Physiology·G D LeSageG Alpini
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F LakehalC Housset
Jun 15, 2006·World Journal of Gastroenterology : WJG·Shannon GlaserGianfranco Alpini
Jun 8, 2007·Histopathology·K KozakaY Nakanuma
Jun 27, 2007·The American Journal of Surgical Pathology·Shinichi AishimaMasazumi Tsuneyoshi
Jul 10, 2007·Progress in Histochemistry and Cytochemistry·Motoko SasakiYasuni Nakanuma
Jun 27, 2008·Annals of Surgery·Itaru EndoWilliam R Jarnagin
Oct 30, 2010·Cancer Science·Shin HamadaTooru Shimosegawa
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mina KomutaTania Roskams
Nov 2, 2012·Human Pathology·Alex HattoumGeorge K Michalopoulos
Jan 1, 2014·The British Journal of Surgery·T EbataM Nagino
Jan 11, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jau-Yu LiauYung-Ming Jeng
Mar 4, 2014·Lancet·Nataliya Razumilava, Gregory J Gores
Jan 1, 2016·Annals of Surgical Oncology·Andrea RuzzenenteAlfredo Guglielmi
Jun 4, 2016·The American Journal of Surgical Pathology·Akimasa HayashiMasashi Fukayama
Mar 25, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Masayuki AkitaYoh Zen
Oct 7, 2017·Anticancer Research·Yuji MorineMitsuo Shimada