A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans

The Journal of Biological Chemistry
Olena K VatamaniukPhilip A Rea

Abstract

Increasing emissions of heavy metals such as cadmium, mercury, and arsenic into the environment pose an acute problem for all organisms. Considerations of the biochemical basis of heavy metal detoxification in animals have focused exclusively on two classes of peptides, the thiol tripeptide, glutathione (GSH, gamma-Glu-Cys-Gly), and a diverse family of cysteine-rich low molecular weight proteins, the metallothioneins. Plants and some fungi, however, not only deploy GSH and metallothioneins for metal detoxification but also synthesize another class of heavy metal binding peptides termed phytochelatins (PCs) from GSH. Here we show that PC-mediated heavy metal detoxification is not restricted to plants and some fungi but extends to animals by demonstrating that the ce-pcs-1 gene of the nematode worm Caenorhabditis elegans encodes a functional PC synthase whose activity is critical for heavy metal tolerance in the intact organism.

References

Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z S LiP A Rea
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y P LuP A Rea
May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·O K VatamaniukP A Rea
Aug 4, 1999·Trends in Microbiology·G I McFadden, D S Roos
Jun 6, 2000·Current Opinion in Plant Biology·C S Cobbett
Jul 8, 2000·British Medical Bulletin·C A Northrop-Clewes, C Shaw
Nov 10, 2000·Primary Care·H Hu

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Citations

Sep 3, 2008·Archives of Microbiology·Daniel Rios-BarreraM Eugenia Torres-Marquez
Apr 27, 2013·Archives of Environmental Contamination and Toxicology·M C ArnoldJ N Meyer
Feb 19, 2009·Applied Biochemistry and Biotechnology·Rama Pal, J P N Rai
Aug 7, 2013·Molecular and Biochemical Parasitology·Coraline RigouinDavid L Williams
Apr 25, 2003·Biochemical and Biophysical Research Communications·Robert WysockiDorota Dziadkowiec
Jan 30, 2002·Trends in Biotechnology·Olena K VatamaniukPhilip A Rea
Oct 18, 2002·Biochimica Et Biophysica Acta·D S GomesE C A Eleutherio
Jul 18, 2002·Trends in Plant Science·Stephan ClemensUte Krämer
Jul 23, 2013·Metallomics : Integrated Biometal Science·Elisa AndresenHendrik Küpper
Jul 4, 2001·European Journal of Biochemistry·S ClemensT Degenkolb
Oct 13, 2010·The Journal of Biological Chemistry·David G Mendoza-CózatlJulian I Schroeder
May 4, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie HallJonathan H Freedman
Sep 18, 2004·Plant Physiology·Philip A ReaDaniel J Rigden
Jan 7, 2003·Applied and Environmental Microbiology·Sandrine Sauge-MerleGilles Peltier
Sep 12, 2002·Annual Review of Plant Biology·Christopher Cobbett, Peter Goldsbrough
Aug 31, 2011·Journal of Toxicology·Ebany J Martinez-Finley, Michael Aschner
Apr 2, 2011·PLoS Genetics·John T MurphyKerry Kornfeld
Jun 2, 2011·PLoS Neglected Tropical Diseases·Debalina Ray, David L Williams
Feb 6, 2013·PLoS Neglected Tropical Diseases·Coraline RigouinDavid L Williams
Nov 28, 2013·PloS One·Manuel LiebekeJacob G Bundy
May 24, 2003·Applied Microbiology and Biotechnology·O V SinghR K Jain
Jan 1, 2002·The Arabidopsis Book·Christopher S Cobbett, Richard B Meagher
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Denis VivaresDavid Pignol
Jul 8, 2005·Analytical and Bioanalytical Chemistry·M H A El-ZohriH Frank
Aug 26, 2014·Molecular Ecology·Ron ElranTamar Lotan
Jun 18, 2004·Immunological Reviews·Hinrich SchulenburgJonathan J Ewbank
Feb 21, 2004·Biochemical and Biophysical Research Communications·Naoki TsujiKazuhisa Miyamoto

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