A New Pharmacokinetic Model Describing the Biodistribution of Intravenously and Intratumorally Administered Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in a GL261 Xenograft Glioblastoma Model

International Journal of Nanomedicine
Alexander P KlapprothGabriele Multhoff

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have displayed multifunctional applications in cancer theranostics following systemic delivery. In an effort to increase the therapeutic potential of local therapies (including focal hyperthermia), nanoparticles can also be administered intratumorally. Therefore, the development of a reliable pharmacokinetic model for the prediction of nanoparticle distribution for both clinically relevant routes of delivery is of high importance. The biodistribution of SPIONs (of two different sizes - 130 nm and 60 nm) radiolabeled with zirconium-89 or technetium-99m following intratumoral or intravenous injection was investigated in C57/Bl6 mice bearing subcutaneous GL261 glioblastomas. Based on PET/CT biodistribution data, a novel pharmacokinetic model was established for a better understanding of the pharmacokinetics of the SPIONs after both administration routes. The PET image analysis of the nanoparticles (confirmed by histology) demonstrated the presence of radiolabeled nanoparticles within the glioma site (with low amounts in the liver and spleen) at all investigated time points following intratumoral injection. The mathematical model confirmed the dynamic nanoparticle redistribution i...Continue Reading

References

Jan 1, 1973·The Journal of Physiology·A C RichesS V Smith
Nov 30, 2005·Journal of Neuro-oncology·Andreas JordanRoland Felix
Jul 20, 2007·Journal of Pharmacokinetics and Pharmacodynamics·Amit Garg, Joseph P Balthasar
Sep 18, 2007·Regulatory Toxicology and Pharmacology : RTP·Werner I HagensAdriënne J A M Sips
Oct 16, 2010·ACS Nano·Mingguang LiJoshua Reineke
Jul 29, 2011·Nanotechnology·A J GiustiniP J Hoopes
Mar 16, 2012·International Journal of Nanomedicine·Mingguang LiJoshua Reineke
May 24, 2012·International Journal of Nanomedicine·Huan XieWilliam T Phillips
Oct 1, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mark J ErnstingShyh-Dar Li
Oct 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guo-qing YiLu-kui Chen
Aug 25, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jennifer E SagerNina Isoherranen
Mar 2, 2016·International Journal of Nanomedicine·Ulrika CarlanderGunnar Johanson
Jun 10, 2016·Current Drug Metabolism·Maxim Shevtsov, Gabriele Multhoff
May 18, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Manashjit GogoiRinti Banerjee
Dec 1, 1995·Evolution; International Journal of Organic Evolution·Marek Konarzewski, Jared Diamond
Jun 29, 2017·Annals of the ICRP·F PaquetUNKNOWN Authors on Behalf of ICRP
Jan 18, 2018·ACS Nano·Maha R A AbdollahKerry Ann Chester
May 20, 2018·Clinical Pharmacokinetics·Venkata YellepeddiCatherine M T Sherwin
Nov 6, 2018·Journal of Pharmaceutical Sciences·Dongfen YuanYanguang Cao
Nov 30, 2018·Expert Opinion on Drug Delivery·Thomas VangijzegemSophie Laurent

❮ Previous
Next ❯

Methods Mentioned

BETA
size exclusion chromatography
X-ray
xenograft

Software Mentioned

Tera
VivoQuant
Mediso
MATLAB
Nucline
TomoTM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.