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A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells

Cell Death & Disease

Sep 12, 2013

Antonella MuscellaSanto Marsigliante

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Abstract

[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, including the cisplatin-resistant human breast carcinoma MCF-7 cells. Here, to confirm that PtAcD has the potentiality for therapeutic intervention, we studied its effects in primary cultured...read more

Mentioned in this Paper

NSC-119875
Antineoplastic Agents
Phosphorylation
Cell Death
Dye Exclusion Assays, Antitumor
Malignant Neoplasm of Breast
Tumor Cells, Malignant
Breast Carcinoma
Protein Kinase M
Mitogen-activated protein kinase p38
Paper Details
References
  • References28
  • Citations9
123
  • References28
  • Citations9
1

A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells

Cell Death & Disease

Sep 12, 2013

Antonella MuscellaSanto Marsigliante

PMID: 24030148

DOI: 10.1038/cddis.2013.315

Abstract

[Pt(O,O'-acac)(γ-acac)(DMS)] (PtAcD) is able to induce apoptosis in various human cancer cells, including the cisplatin-resistant human breast carcinoma MCF-7 cells. Here, to confirm that PtAcD has the potentiality for therapeutic intervention, we studied its effects in primary cultured...read more

Mentioned in this Paper

NSC-119875
Antineoplastic Agents
Phosphorylation
Cell Death
Dye Exclusion Assays, Antitumor

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Paper Details
References
  • References28
  • Citations9
123
  • References28
  • Citations9
1

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