A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size

Biochemical Society Transactions
Thomas PorstmannAlmut Schulze

Abstract

Cell growth requires co-ordinated regulation of processes that provide metabolites for the synthesis of macromolecules such as proteins and membrane lipids. In recent years, a lot of emphasis has been placed on the activation of protein synthesis by mTORC1 (mammalian target of rapamycin complex 1). The contribution of anabolic pathways other than protein synthesis has only been considered recently. In the present paper, we discuss recent findings regarding the contribution of transcriptional regulation of lipogenesis genes by the SREBP (sterol-regulatory-element-binding protein) transcription factor, a central regulator of expression of lipogenic genes, to the control of cell size in vitro and cell and organ size in vivo.

References

Jul 10, 1999·The Journal of Biological Chemistry·A BarthelR A Roth
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Brown, J L Goldstein
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ShimomuraJ L Goldstein
Sep 12, 2000·Current Opinion in Genetics & Development·H Stocker, E Hafen
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sara C Kozma, George Thomas
Feb 8, 2002·Developmental Cell·Adam C SeegmillerRobert B Rawson
Mar 23, 2002·Molecular and Cellular Biology·Tetsuo ShioiSeigo Izumo
Jul 23, 2002·Molecular Biology of the Cell·Aimee L Edinger, Craig B Thompson
Feb 1, 2003·Trends in Cell Biology·Sean Oldham, Ernst Hafen
Mar 18, 2003·Molecular and Cellular Biology·Valeria GiandomenicoJohan Ericsson
Sep 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jay D HortonJoseph L Goldstein
Oct 1, 2003·Molecular and Cellular Biology·Jeffrey C RathmellCraig B Thompson
May 19, 2005·The Journal of Biological Chemistry·Li-Ping SunMichael S Brown
Jul 12, 2005·Oncogene·Daniel E BauerCraig B Thompson
Oct 18, 2005·Current Opinion in Cell Biology·Dos D SarbassovDavid M Sabatini
Oct 18, 2005·Cancer Cell·Georgia HatzivassiliouCraig B Thompson
Nov 17, 2005·Oncogene·David R Plas, Craig B Thompson
Dec 31, 2005·American Journal of Physiology. Cell Physiology·Min Lu, John Y-J Shyy
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Jun 7, 2006·Cell Metabolism·Amit S KunteRobert B Rawson
Aug 2, 2006·Cell Cycle·Maria T Bengoechea-Alonso, Johan Ericsson
Jan 12, 2007·Molecular Biology of the Cell·Xiangyu Liu, X F Steven Zheng
Feb 6, 2007·Nature Cell Biology·Emilie Vander HaarDo-Hyung Kim
Feb 17, 2007·Current Opinion in Cell Biology·Maria T Bengoechea-Alonso, Johan Ericsson
Mar 28, 2007·Molecular Cell·Yasemin SancakDavid M Sabatini
May 19, 2007·The Journal of Biological Chemistry·Lifu WangJohn C Lawrence
Jul 3, 2007·Cell·Brendan D Manning, Lewis C Cantley
Sep 21, 2007·Nature Reviews. Cancer·Javier A Menendez, Ruth Lupu
Nov 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ralph J DeBerardinisCraig B Thompson
Jan 8, 2008·Cell Metabolism·Ralph J DeBerardinisCraig B Thompson
May 13, 2008·Molecular Cell·D Grahame Hardie
Jul 8, 2008·Biochemical and Biophysical Research Communications·Laura J Sharpe, Andrew J Brown
Sep 3, 2008·Cell Metabolism·Thomas PorstmannAlmut Schulze

❮ Previous
Next ❯

Citations

Mar 27, 2013·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B C Melnik
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Beatrice T WangKevan M Shokat
Mar 27, 2013·Annual Review of Nutrition·Donald B JumpChristopher M Depner
Aug 9, 2013·Journal of Lipid Research·Laura V DanaiMichael P Czech
Apr 7, 2011·Experimental & Molecular Medicine·Chang Hoon Cho
Mar 20, 2010·The Journal of Nutrition·Kyle T PfaffenbachMichael J Pagliassotti
Jul 6, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xia ZhangXuejun Gao
Aug 2, 2011·Biotechnology Advances·F ChiaradonnaL Alberghina
Feb 2, 2010·Trends in Endocrinology and Metabolism : TEM·James R KrycerAndrew J Brown
Nov 8, 2012·Pediatric Transplantation·Irena JankowskaJoanna Pawłowska
Jul 7, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Goran Klintmalm, Cliona O'Farrelly
Nov 26, 2013·Journal of Neurochemistry·Stephen A BroseMikhail Y Golovko
Mar 25, 2011·Biochemical Society Transactions·Ivana Bjedov, Linda Partridge
Apr 8, 2014·Biochemical and Biophysical Research Communications·María Soledad AlvarezMarta Casado
Nov 30, 2013·Biochimica Et Biophysica Acta·Beatriz Sánchez-SolanaRakesh Kumar
Mar 29, 2011·Biochimica Et Biophysica Acta·Nissim Hay
Feb 27, 2014·Biochimica Et Biophysica Acta·Daniele Lettieri BarbatoMaria Rosa Ciriolo
Dec 2, 2009·Current Biology : CB·Mathieu Laplante, David M Sabatini
Mar 24, 2012·World Journal of Diabetes·Bodo C Melnik
May 17, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yassine El HianiXian-Ping Dong
Oct 28, 2011·American Journal of Physiology. Renal Physiology·Lalita UttarwarJoan C Krepinsky
Jan 16, 2009·Biochemical Society Transactions·Deborah C I Goberdhan, C A Richard Boyd
Jul 10, 2010·The Journal of Biological Chemistry·You-Mie KimGyesoon Yoon
Mar 16, 2017·Cancer Science·Masahiro Takikawa, Rieko Ohki
Apr 26, 2013·Experimental Dermatology·Bodo C Melnik, Christos C Zouboulis
Apr 28, 2012·The Journal of Experimental Biology·Popko WiersmaJoseph B Williams
May 31, 2021·Biochemical Pharmacology·Miguel A LasunciónDiego Gómez-Coronado
Jul 27, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Zofia ChrienovaKamil Kuca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.