A new porcine sponge material for temporary embolization: an experimental short-term pilot study in swine

Cardiovascular and Interventional Radiology
B LouailJ-C Gaux

Abstract

To evaluate the safety and efficacy of a porcine-derived gelfoam, Curaspon, for the temporary occlusion of the visceral arteries. Curaspon was used for the selective embolization of segmentary hepatic, unilateral polar renal, and single lumbar arteries of 10 pigs under general anesthesia. Sequential angiographic checks were carried out and the pigs killed between 3 days and 2 weeks later. Macroscopic and microscopic studies using standard techniques were used to evaluate the immediate efficacy of embolization, duration of and completeness of recanalization on angiography, macroscopic appearance of target-organ ischemia, and microscopic analysis of inflammatory reaction. Immediate arterial occlusion was obtained in all cases. Renal arteries showed a total recanalization in 63% of cases on day 7 and 100% on day 14. Total hepatic recanalization was obtained in 100% of animals on day 7. All lumbar arteries were recanalized on day 14. Microscopic analysis in the kidney revealed a mild inflammatory reaction and a progressive lysis of the Curaspon (87% of samples at day 3 showed a persistence of Curaspon and 5% at day 14). In some cases, localized and partial destruction of the arterial wall was visualized. In the liver the same patte...Continue Reading

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Citations

May 18, 2013·Expert Opinion on Drug Delivery·Paolo GiunchediGiovanna Rassu
Sep 24, 2015·Cardiovascular and Interventional Radiology·Thierry de BaereMichael C Soulen
Sep 29, 2011·Journal de radiologie·O Pellerin, J-F Geschwind
Jan 5, 2011·Journal of Vascular and Interventional Radiology : JVIR·Yuzo ShomuraSatoshi Sawada
Jun 11, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Blandine CourbiereMarc Gamerre
Jun 24, 2008·Techniques in Vascular and Interventional Radiology·Hicham T Abada, Jafar Golzarian
Dec 11, 2013·Acta Biomaterialia·Stéphanie LouguetLaurence Moine
May 27, 2016·The Journal of Obstetrics and Gynaecology Research·Yuko NakamuraFumiki Hirahara
Jul 5, 2016·Journal of Visceral Surgery·J FrandonF Thony
Jul 15, 2016·Cardiovascular and Interventional Radiology·Gregory AmouyalMarc Sapoval
Dec 7, 2017·Journal of Biomaterials Applications·Christof M SommerStephan Macher-Göppinger
Jun 10, 2020·Cardiovascular and Interventional Radiology·Matthias StecheleFlorian Streitparth
May 3, 2019·Cardiovascular and Interventional Radiology·Yongsheng YeXiaomei Wu
Oct 26, 2021·Cardiovascular and Interventional Radiology·Pierleone LucatelliThomas Helmberger

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