A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
H F VanBrocklinSimon Ametamey

Abstract

For the electrophilic preparation of 6-[18F]fluoro-L-m-tyrosine ([18F]FMT), a PET tracer for measuring changes in dopaminergic function in movement disorders, a novel precursor, N-(tert-butoxycarbonyl)-3-(tert-butoxycarbonyloxy)-6-trimethylstannnyl-L-phenylalanine ethyl ester, was synthesized in four steps and 26% yield starting from L-m-tyrosine. [18F]FMT produced by two methods at two institutions was comparable in both radiochemical yield, 25-26%, and quality (chemical, enantiomeric, and radiochemical purity and specific activity) as that obtained with the original N-trifluoroacetyl-3-acetyl-6-trimethylstannyl-L-m-tyrosine ethyl ester [18F]FMT precursor.

References

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Citations

May 30, 2012·Journal of Cognitive Neuroscience·Linh C DangWilliam J Jagust
May 9, 2014·PloS One·Deanna L WallaceMark D'Esposito
Jul 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linh C DangWilliam J Jagust
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meredith N BraskieWilliam J Jagust
Dec 12, 2012·Environmental Science and Pollution Research International·Julie MovellanJean-François Chollet
Jan 12, 2016·Chemical Reviews·Sean PreshlockVéronique Gouverneur
Jul 18, 2006·Nuclear Medicine and Biology·Michael HonerSimon M Ametamey
Apr 23, 2011·Neurobiology of Aging·Ellen C KlostermannWilliam J Jagust
Feb 15, 2014·Psychological Science·Esther AartsMark D'Esposito
Aug 18, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne S BerryWilliam J Jagust
Jul 10, 2014·Nature Communications·Benjamin H RotsteinSteven H Liang
May 29, 2012·Angewandte Chemie·Zhanghua GaoVéronique Gouverneur
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Johannes Ermert, Heinz H Coenen
Mar 27, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Johnny Castillo MeleánHeinz H Coenen
Jun 12, 2014·Angewandte Chemie·Matthew TredwellVéronique Gouverneur

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