PMID: 6170170Jan 1, 1981Paper

A new preparation of modified immune serum globulin (human) suitable for intravenous administration. II. Functional characterization

Vox Sanguinis
D D SchroederJ L Lundblad

Abstract

The commercial immune serum globulin (ISG) product is suitable for use in passive immunization only by intramuscular administration; intravenous use results in vasomotor side reactions. We report the functional characterization of a chemically modified ISG (MISG) that is essentially free of nonspecific complement-binding activity and contains no new antigenic determinants. The half-life values for MISG given intravenously to rabbits, guinea pigs, and humans are shown not to be different from that of ISG. The MISG we describe is shown to fulfill the in vitro and in vivo criteria of stability, safety, function, and half-life, making it suitable for human intravenous administration.

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Citations

Jun 20, 2006·Journal of Clinical Immunology·Erwin W GelfandUNKNOWN IGIV-C Increased Maximum Infusion Rate Study Group
May 30, 1992·Lancet·D L Tankersley, J S Finlayson
Feb 6, 2016·International Journal of Molecular Sciences·Houzong YaoGe Zhang
Aug 1, 1988·The Journal of Hospital Infection·J L Lundblad, N Londeree
Feb 18, 2014·Expert Review of Clinical Immunology·Richard L Wasserman
Jan 1, 1983·Journal of Clinical Apheresis·P C Dau
Nov 24, 2005·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Erwin W Gelfand
Jul 23, 2004·Expert Opinion on Investigational Drugs·A Razzaque Ahmed
Mar 30, 1984·The American Journal of Medicine·D H Bing

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