A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors

BJU International
Tilman TodenhöferGeorgios Gakis

Abstract

Study Type - Prognosis (cohort series) Level of Evidence 2a What's known on the subject? and What does the study add? Preoperative thrombocytosis has been identified as a predictor of poor outcome in various cancer types. However, the prognostic role of platelet count in patients with invasive bladder cancer undergoing radical cystectomy is unknown. The present study demonstrates that preoperative thrombocytosis is an independent risk factor for decreased cancer-specific survival after radical treatment of invasive bladder cancer. We developed a new prognostic scoring model for cancer-specific outcomes after radical cystectomy including platelet count and established pathological risk factors. Consideration of platelet count in the final model increased its predictive accuracy significantly. Thrombocytosis may be a useful parameter to include within established international bladder cancer nomograms. •  To investigate the oncological significance of preoperative thrombocytosis in patients with invasive bladder cancer undergoing radical cystectomy, as it has been reported as a marker for aggressive tumour biology in a variety of solid tumours. •  The series comprised 258 patients undergoing radical cystectomy between 1999 and 20...Continue Reading

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Citations

Feb 26, 2013·European Journal of Internal Medicine·Hadi A GoubranMagdy El-Ekiaby
Sep 1, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Georgios Gakis
Jan 1, 2015·Bladder Cancer·Kevin KrughoffShandra Wilson
Jan 13, 2015·World Journal of Urology·Mauro SemiliaTilman Todenhöfer
Feb 25, 2015·European Urology·Luis A KluthShahrokh F Shariat
Aug 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Georgios GakisMichael Rink
Jun 6, 2020·Scandinavian Journal of Urology·Georgios GakisMarkus Renninger
Jul 28, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ching Ying LinZihai Li

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