A New Prognostic Score Supporting Treatment Allocation for Multimodality Therapy for Malignant Pleural Mesothelioma: A Review of 12 Years' Experience

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Isabelle OpitzWalter Weder

Abstract

Treatment of malignant pleural mesothelioma (MPM) remains a clinical challenge. The aim of this study was to identify selection factors for allocation of MPM patients to multimodal therapy based on survival data from 12 years of experience. Eligible patients had MPM of all histological subtypes with clinical stage T1-3 N0-2 M0. Induction chemotherapy consisted of cisplatin/gemcitabine (cis/gem) or cisplatin/pemetrexed (cis/pem), followed by extrapleural pneumonectomy (EPP). Multivariate analysis was performed to assess independent prognosticators for overall survival (OS). A Multimodality Prognostic Score was developed based on clinical variables available before surgery. From May 1999 to August 2011, 186 MPM patients were intended to be treated with induction chemotherapy followed by EPP. Hematologic toxicity was significantly less frequent after cis/pem compared to cis/gem, but there was no difference in response or OS between the regimens. One hundred and twenty-eight patients underwent EPP with a 30-day mortality of 4.7%. Fifty-two percent of the patients received adjuvant radiotherapy. The median OS of patients undergoing EPP was significantly longer with 22 months (95% confidence interval: 20-24) when compared to 11 month...Continue Reading

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Citations

Mar 26, 2016·Expert Review of Respiratory Medicine·Pietro Bertoglio, David A Waller
Apr 13, 2019·Expert Review of Respiratory Medicine·Kyrillus Shohdy, Omar Abdel-Rahman
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
May 26, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Isabelle OpitzGiuseppe Cardillo
Jun 1, 2018·International Journal of Molecular Sciences·Kathrin OehlMayura Meerang
Apr 30, 2017·Interactive Cardiovascular and Thoracic Surgery·Arthur KostronIsabelle Opitz
May 27, 2020·The European Respiratory Journal·Arnaud ScherpereelPaul Martin Putora
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Nov 14, 2020·Current Opinion in Oncology·Katharina SinnM Alireza Hoda
Mar 14, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Francoise Galateau SalleNicolas Girard
Jun 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jingzhe WangHuabiao Chen
Feb 7, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kathrin OehlPeter J Wild
Jun 16, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I Opitz, W Weder

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