A new prostatic cancer model: systemic induction of prostatic cancer in rats by a nitrosamine

Cancer Letters
P M Pour

Abstract

Weekly intragastric application of N-nitrosobis(2-oxopropyl) amine (BOP) at a dose of 10 mg/kg body wt induced prostatic cancer in 5 out of 15 MRC rats. Hyperplasia and metaplasia of the prostatic gland were found in 13 rats with or without cancer. All tumors had developed in the dorsal lobe, had reached a size of up to 20 mm and were invasive. Distant metastases were not observed. Although hyperplastic lesion were of a glandular type, all carcinomas had squamous cell character. All cases of prostatic cancer were associated with papillomas or carcinomas of the urethral epithelium, which had initially developed in the colliculus seminalis. The induction of prostatic cancer for the first time by a systemic application by a nitrosamine provides a promising model for understanding basic principals of prostatic cancer.

References

Jan 1, 1977·Oncology·M PollardP H Luckert

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Citations

Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·M Pollard
Apr 1, 1985·Journal of Steroid Biochemistry·P I LundmoK J Tveter
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Sep 14, 2012·Toxicologic Pathology·Dianne CreasyKatharine Whitney
Jan 22, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Farkhondeh PouresmaeiliMaryam Kamarehei

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