A New QT Interval Correction Formulae to Adjust for Increases in Heart Rate

JACC. Clinical Electrophysiology
Simon W RabkinDarby J S Thompson

Abstract

This study sought to develop a formula from a large population-based study that best fit the QT-heart rate (HR) relationship independent of the standard mathematical relationships. Attempts to adjust or correct for the impact of HR on the QT interval (QTc) have applied various mathematical equations to electrocardiographic (ECG) data rather than allowing the data to determine the form of the relationship. A spline correction function was developed using the ECG data from NHANES (National Health and Nutrition Examination Surveys) II and III. The magnitude of linear, quadratic, and cubic trends in the relationship between HR and each QTc was quantified using an F-statistic with differences between QTcs compared using a permutation procedure. The effect of HR on QT was obliterated by the spline QT for both men and women. The cross-validated spline QTc was superior (i.e., flatter) to 6 other formulae, including ones proposed previously. In ECGs from the clinic with HRs faster than 70 beats/min, the QTcs from different formulae were significantly (p < 0.0001) different from one another. Individual values suggest the use of the longest and shortest QTc intervals as developed originally. The new QTc and its population percentile ranki...Continue Reading

References

Sep 15, 1992·The American Journal of Cardiology·A SagieD Levy
Aug 26, 1993·The American Journal of Cardiology·C Funck-Brentano, P Jaillon
Oct 1, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·L S Fridericia
Mar 5, 2004·The New England Journal of Medicine·Dan M Roden
Jul 3, 2010·Molecular Genetics and Metabolism·Nilesh J BokilKim M Summers
Jul 9, 2010·The American Journal of the Medical Sciences·Anthony D WhittedKarl T Weber
Jul 2, 2015·World Journal of Cardiology·Simon W Rabkin, Xin Bo Cheng
Feb 22, 2016·The American Journal of the Medical Sciences·Simon W Rabkin, XinBo Justin Cheng

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Citations

Mar 20, 2019·International Journal of Molecular Sciences·Robert M LesterIan A Johnson
Sep 12, 2019·Journal of Clinical Medicine·Santiago ColungaDavid Calvo
Oct 19, 2017·Circulation. Arrhythmia and Electrophysiology·David F Briceño, Gregory E Supple
Nov 24, 2020·Cardiology Research and Practice·Simon W Rabkin, Jacky K K Tang
Jan 20, 2021·Journal of Electrocardiology·Ishmeet Singh, Simon W Rabkin
Jul 14, 2021·Scientific Reports·Irena AndršováMarek Malik

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