PMID: 1180257Sep 1, 1975Paper

A new rapid differentiating solubility test for hemoglobin S.

The American Journal of Medical Technology
B WarrenG L Evans

Abstract

A new test for sickling hemoglobin, SickleQuikTM, has been developed which has definitive advantages over existing turbidity tests. This test utilizes a biphasic liquid reagent system provided in individualized, ready-to-use reaction tubes which are stable at room temperature. The test differentiates homozygous from heterozygous S samples in less than eight minutes. Results are based on the color of a layer formed at the organic-aqueous interface and the color of the lower aqueous phase. Of more than 900 samples tested in independent laboratories, no false positive or false negative results occurred.

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