A new role for AMP-activated protein kinase in the circadian regulation of L-type voltage-gated calcium channels in late-stage embryonic retinal photoreceptors

Journal of Neurochemistry
Cathy C Y HuangGladys Y-P Ko

Abstract

AMP-activated protein kinase (AMPK) is a cellular energy sensor, which is activated when the intracellular ATP production decreases. The activities of AMPK display circadian rhythms in various organs and tissues, indicating that AMPK is involved in the circadian regulation of cellular metabolism. In vertebrate retina, the circadian clocks regulate many aspects of retinal function and physiology, including light/dark adaption, but whether and how AMPK was involved in the retinal circadian rhythm was not known. We hypothesized that the activation of AMPK (measured as phosphorylated AMPK) in the retina was under circadian control, and AMPK might interact with other intracellular signaling molecules to regulate photoreceptor physiology. We combined ATP assays, western blots, immunostaining, patch-clamp recordings, and pharmacological treatments to decipher the role of AMPK in the circadian regulation of photoreceptor physiology. We found that the overall retinal ATP content displayed a diurnal rhythm that peaked at early night, which was nearly anti-phase to the diurnal and circadian rhythms of AMPK phosphorylation. AMPK was also involved in the circadian phase-dependent regulation of photoreceptor L-type voltage-gated calcium chan...Continue Reading

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Citations

Sep 3, 2017·Journal of Neuroscience Research·Julia P SegalNader Ghasemlou
Oct 3, 2018·The European Journal of Neuroscience·Gladys Y-P Ko
Apr 20, 2018·Journal of Biological Rhythms·Janet Ya-An ChangGladys Y-P Ko
Oct 27, 2020·American Journal of Physiology. Endocrinology and Metabolism·Karina BermeoDavid E Garcia

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