Abstract
The low affinity receptor for IgE, CD23, has been described in several pathological conditions. However, the factors involved in the upregulation or downregulation of this receptor are still debated. We studied the effect of interleukin 7 (IL-7) on the expression of CD23 in normal PBT cells stimulated with PMA + Ca2. The data indicate that activated PB-T cultured in the presence of IL-7 showed an increased expression of CD23. The induction of IL-7 on CD23 production appears to be independent of IL-2, IL-4, IL-9, IL-15. Indeed, the addition of specific MoAbs anti-IL-2, IL-4, IL-9, IL-15 or anti-IL2R was unable to block the effect of IL-7 on CD23. The addition of IL-7 to a specific subset CD4+ CD23+ was able to augment the adhesiveness of T cells to parenchymal cell monalayers. The use of different cytokine (IL-2, IL-4, IL-9, IL-15) resulted in no increase of adhesiveness. In contrast the addition of IL-7 to a different T-cell subset (i.e. CD4+ CD23-) was unable to rescue the lack of adhesiveness observed in these cells. Blocking experiments with MHM6 MoAb were able to drastically reduce the adhesiveness observed in CD4+ CD23+ subsets. The presence of LFA-1 and VLA-4 adhesion molecules were responsible for the augmented adhesiven...Continue Reading
References
Jan 1, 1979·Scandinavian Journal of Immunology·U Hellström, H L Spiegelberg
May 1, 1990·Cellular Immunology·H MontzO Götze
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A KupferH Kupfer
Feb 1, 1990·European Journal of Immunology·M LondeiM Feldmann
Apr 1, 1991·The Journal of Experimental Medicine·M R AldersonK H Grabstein
Jun 1, 1990·European Journal of Immunology·J C PrinzE P Rieber
Aug 1, 1990·The Journal of Experimental Medicine·M R AldersonM B Widmer
Nov 1, 1990·European Journal of Immunology·L Flores-RomoJ Gordon
Mar 1, 1989·The Journal of Experimental Medicine·P J MorrisseyS G Reed
Dec 1, 1989·Current Opinion in Immunology·A Kelso
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G GoodwinA E Namen
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G D ChazenE M Shevach
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T MatsubasaM Mori
Jul 1, 1986·European Journal of Immunology·T Nakajima, G Delespesse
Jul 1, 1986·European Journal of Immunology·G DelespesseT Wolowiec
Jun 1, 1987·European Journal of Immunology·J C PrinzE P Rieber
Jan 1, 1988·The Journal of Experimental Medicine·J Y BonnefoyJ Banchereau
Mar 24, 1988·Nature·W J PooC A Janeway
Jun 1, 1985·Clinical Immunology and Immunopathology·T NagaiH Uchino
Jan 1, 1985·International Archives of Allergy and Applied Immunology·H L SpiegelbergR H Buckley
Jun 9, 1988·Nature·A E NamenS Gillis
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C CariniK Ishizaka
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·M RoweM A Epstein
Feb 1, 1994·AIDS Research and Human Retroviruses·C Carini, M Essex
Jan 1, 1995·International Immunology·Y KimuraK Sugamura
Apr 1, 1995·Immunity·J X LinS John
Mar 11, 1994·Science·M KondoK Sugamura
Dec 17, 1993·Science·M NoguchiW J Leonard
Dec 17, 1993·Science·S M RussellW E Paul
Jan 1, 1993·International Archives of Allergy and Immunology·C CariniC Fratazzi
May 1, 1996·International Archives of Allergy and Immunology·C Carini, C Fratazzi